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  • Posterior cranial fossa  (2)
  • Insulin receptor  (1)
  • Lumbordorsal spine  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Tyrosine kinase activity of insulin receptors from an insulin-resistant patient with leprechaunism (1987)
    Springer
    Diabetologia 30 (1987), S. 631-637 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Insulin receptor ; tyrosine kinase ; insulin resistance ; anti-receptor antibodies ; leprechaunism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Defects in insulin receptor function can impair the response of target cells to insulin. Previously we have described an insulin resistant patient (leprechaun/Ark−1) with qualitative abnormalities in insulin binding suggestive of a structural defect in her insulin receptors. In the present work, we have studied the tyrosine kinase activity associated with insulin receptors from cultured Epstein-Barr virus-transformed lymphocytes. In studies of insulin receptors from leprechaun/Ark−1, we observed that both the magnitude and the dose-dependency of insulin's effect to stimulate the tyrosine kinase activity were normal. This suggests that the defect causing this patient's insulin resistance is independent of the receptor-associated tyrosine kinase. In the course of these studies, we noted that an anti-receptor antiserum (B−d) had a markedly decreased ability to immunoprecipitate insulin receptors from leprechaun/Ark−1. This observation further supports our previous conclusion that the insulin receptor from leprechaun/Ark−1 is abnormal in structure. Moreover, it emphasizes the importance of choosing anti-receptor antisera which are equally effective at immunoprecipitating receptors from both patients and normal subjects when the anti-receptor antisera are employed as reagents in investigations of receptors from insulin-resistant patients.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00277320
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  • 2
    Digitale Medien
    Digitale Medien
    Percutaneous interbody osteosynthesis in the treatment of thoracolumbar traumatic or tumoural lesions (1990)
    Springer
    Acta neurochirurgica 102 (1990), S. 42-53 
    Details
    ISSN: 0942-0940
    Schlagwort(e): Lumbordorsal spine ; interbody osteosynthesis ; percutaneous
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The authors describe a technique of percutaneous interbody osteosynthesis applicable to the dorsal and lumbar spine. 51 patients were so treated for different aetiologies:traumatic conditions (35 cases) andtumoural lesions (16 cases). The material used consisted of special instruments that are positioned in double obliquity by a percutaneous posterolateral approach. A posterior approach limited to the pathological focus was used jointly whenever a graft or a decompression was necessary (19 cases). Several types of anaesthesia were used (local, local-regional, general, neuroleptanalgesia). The patients benefited by the advantages that usually accompany percutaneous techniques. The advantages and limitations of the method are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01402185
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Ependymomas of the posterior cranial fossa: CT and MRI findings (1995)
    Springer
    Neuroradiology 37 (1995), S. 238-243 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Ependymoma ; Posterior cranial fossa ; Children ; Magnetic resonance imaging ; Computed tomography ; Brain tumours
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We studied nine children with posterior cranial fossa ependymomas to identify specific neuroradiological features. Patients were studied preoperatively with CT and MRI; T1-, T2-and proton-density (PD)-weighted images were obtained. All children underwent surgery and a definite histopathological diagnosis was made. All the tumours grew into the fourth ventricle and caused dilatation of its upper part, which resembled a cap. All but one were separated from the vermis by a cleavage plane. In eight cases there was desmoplastic development through the foramina of the fourth ventricle, and five were heterogeneous due to necrosis and cystic change; one had a haemorrhagic area. In most cases the solid portion was isointense with grey matter on T1-weighted images, hyperintense on PD weighting, and isointense on T2-weighted images. On CT the tumour was isodense in six cases and calcification was detected in four. The presence of both desmoplastic development and a tumour/vermis cleavage plane in a posterior cranial fossa tumour isodense on CT is highly suggestive of ependymoma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01578265
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Ependymomas of the posterior cranial fossa: CT and MRI findings (1995)
    Springer
    Neuroradiology 37 (1995), S. 238-243 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Key words Ependymoma ; Posterior cranial fossa ; Children ; Magnetic resonance imaging ; Computed tomography ; Brain tumours
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We studied nine children with posterior cranial fossa ependymomas to identify specific neuroradiological features. Patients were studied preoperatively with CT and MRI; T1-, T2- and proton-density (PD)-weighted images were obtained. All children underwent surgery and a definite histopathological diagnosis was made. All the tumours grew into the fourth ventricle and caused dilatation of its upper part, which resembled a cap. All but one were separated from the vermis by a cleavage plane. In eight cases there was desmoplastic development through the foramina of the fourth ventricle, and five were heterogeneous due to necrosis and cystic change; one had a haemorrhagic area. In most cases the solid portion was isointense with grey matter on T1-weighted images, hyperintense on PD weighting, and isointense on T2-weighted images. On CT the tumour was isodense in six cases and calcification was detected in four. The presence of both desmoplastic development and a tumour/vermis cleavage plane in a posterior cranial fossa tumour isodense on CT is highly suggestive of ependymoma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01578265
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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