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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetic and metabolic aspects of the moclobemide-food interaction (1992)
    Springer
    Psychopharmacology 106 (1992), S. S37 
    Details
    ISSN: 1432-2072
    Keywords: Moclobemide ; Pharmacokinetics ; Interaction ; Food effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of a protein-rich meal on the pharmacokinetics of moclobemide was studied after intravenous (75 mg) and oral (100 mg) administrations of this selective MAO-A inhibitor to eight healthy male volunteers. The meal chosen did not affect plasma concentration-time curves of the drug after oral administration apparently, because the influence of blood flow changes to the liver on hepatic first-pass metabolism (AUC↑) and on systemic clearance (AUC↓) balance each other out.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246232
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    A single dose of azathioprine does not affect the pharmacokinetics of prednisolone following oral prednisone (1981)
    Springer
    European journal of clinical pharmacology 19 (1981), S. 209-212 
    Details
    ISSN: 1432-1041
    Keywords: prednisone ; prednisolone ; azathioprine ; 11 β-hydroxydehydrogenase ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Clinical and pharmacokinetic observations suggest that azathioprine may diminish the plasma level of prednisolone. To study the extent of this possible interaction, and to define the underlying mechanism, total and unbound prednisolone and total prednisone concentrations were assessed in 11 subjects following an oral dose of prednisone once with and once without concomitant oral administration of azathioprine. Azathioprine did not affect the area under the plasma concentration-time curve of total and unbound prednisolone; furthermore, the interconversion of prednisone into prednisolone was not influenced by azathioprine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561951
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Influence of moclobemide on ibuprofen-induced faecal blood loss (1992)
    Springer
    Psychopharmacology 106 (1992), S. S40 
    Details
    ISSN: 1432-2072
    Keywords: Moclobemide ; Ibuprofen ; Interaction ; Pharmacokinetics ; Pharmacodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a pharmacological screen on drug-drug interactions performed in laboratory animals moclobemide potentiated at high doses the antiphlogistic/anti-inflammatory activity of ibuprofen. Therefore, a study was undertaken to determine in healthy volunteers the faecal blood loss induced by multiple doses of ibuprofen (600 mg t.i.d.) in presence and absence of steady-state concentrations of concomitantly administered moclobemide (150 mg t.i.d.). The results show that multiple doses of moclobemide do not change faecal blood loss induced by ibuprofen. Furthermore, no clinically relevant pharmacokinetic interaction between the two drugs studied was detected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246233
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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