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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Urological research 22 (1994), S. 21-23 
    ISSN: 1434-0879
    Keywords: Bladder cancer ; Photodynamic therapy ; Intravenous injection ; Intravesical instillation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Photodynamic therapy (PDT) consists in administration of a photosensitizer and subsequent irradiation of the tumor with visible light. Routinely the photosensitizer is given intravenously (i.v.). The goal of our study was to examine whether intravesical (i.b.) instillation of the photosensitizer for PDT of bladder cancer might be feasible. Therefore, the uptake of chlor-aluminum-sulfonated phthalocyanine (CASPc) in bladder, bladder tumor, skin, and muscle in a rat bladder cancer model after i.v. injection and i.b instillation was compared. The efficacy of PDT after either method of administration was also evaluated. The CASPc concentration in bladder tumor after i.v. injection was approximately 1.5-fold that after i.b. instillation. The ratio of CASPc concentration between bladder tumor and normal bladder was approximately 2:1 after administration by either route. There was no systemic absorption of CASPc after i.b. instillation; hence no systemic side effects are expected. PDT showed similar effects on bladder tumor after either method of administration, but less side effects on normal bladder wall after i.b instillation. Our results demonstrate that i.b. instillation of CASP for PDT of superficial bladder cancer seems to have advantages over i.v. injection.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-0563
    Keywords: Key words Incontinence • Collagen ; Schlüsselwörter Inkontinenz • Kollagen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Minimal invasive Methoden in der Behandlung der Streßharninkontinenz erfreuen sich zunehmender Beliebtheit. An der urologischen Universitätsklinik Ulm wird seit 4/93 die transurethrale Kollageninjektion durchgeführt. Es wurden bisher 48 Patienten (26 Männer und 22 Frauen) behandelt. Bei den Männern bestand die Ursache der Harninkontinenz in einem Zustand nach radikaler Prostatektomie (n = 19) oder TURP (n = 7). Bei allen Frauen (n = 22) war zumindest eine Harninkontinenzoperation vorangegangen. Bei den Patienten wurden im Mittel 1,8 Behandlungen durchgeführt, bei denen durchschnittlich 14,5 ml Kollagen injiziert wurde. Bei einer mittleren Nachbeobachtungszeit von 9,2 Monaten sind 68,2 % der weiblichen Patienten sozial kontinent. Bei den Männern sind 47,3 % nach radikaler Prostatektomie und 6 von 7 Patienten nach TURP sozial kontinent. Bei den Männern war das postoperative Ergebnis v. a. abhängig von der Restfunktion des Sphinkterapparates. Insgesamt muß die transurethrale Kollageninjektion in der Behandlung der Streßharninkontinenz als eine interessante minimal invasive Ergänzung im therapeutischen Armamentarium angesehen werden. Dies setzt aber in jedem Fall eine sorgfältige Patientenselektion voraus.
    Notes: Summary Minimally invasive treatment of urinary incontinence has become a subject of major interest in recent years. We examined the use of transurethral collagen injection for incontinence treatment. A total of 48 patients were selectet for this procedure from April 1993 to February 1997 – 26 male patients (19 post-RPX incontinence and 7 post-TUR incontinence) and 22 female patients (all after previous incontinence surgery) were treated by injection of collagen into the continence region. The whole group underwent an average of 1.8 sessions, and a mean collagen injection volume of 14.5 ml was delivered per session. Mean follow-up was 9.2 months. Of the female population, 68.2 % were cured or greatly improved. In the male population only 47.3 % of the post-RPX patients and 6/7 of the post-TUR patients benefited from the procedure. In males, treatment outcome depends on the degree of pretreatment incontinence, because all grade III incontinence patients did worse. Therefore we conclude: transurethral collagen injection is an interesting method in the treatment of urinary incontinence if proper patient selection is assured.
    Type of Medium: Electronic Resource
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