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  • 1
    Electronic Resource
    Electronic Resource
    INFLUENCE OF COLD EXPOSURE ON THE ACTIVITIES OF SOLUBLE AND MEMBRANE-BOUND DOPAMINE β-HYDROXYLASE IN RAT HEART VESICLES (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 27 (1976), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— A fraction containing noradrenaline storage vesicles of the sympathetic nerve terminals in the rat heart was obtained by differential centrifugation. In this preparation, 17% of the dopamine β-hydroxylase was present in a soluble form. Cold exposure (3°C) for periods from 5 to 30 min led to an increase in the activity of soluble dopamine β-hydroxylase by about 50%, while the activity of membrane-bound dopamine β-hydroxylase was simultaneously decreased by approx 30%. The nor-adrenaline content of the vesicles rose concomitantly with the increase in the activity of soluble dopamine β-hydroxylase. This rise in noradrenaline content was caused by an enhanced synthesis and not by an alteration in the subcellular distribution. The results are discussed with respect to the fate of dopamine β-hydroxylase during enhanced sympathetic nerve activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1976.tb12265.x
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  • 2
    Electronic Resource
    Electronic Resource
    Studies on the mechanism of the positive inotropic action evoked by epinine on the rabbit isolated papillary muscle at different rates of beating (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 6 (1979), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Effects of epinine on cyclic AMP and contractility were investigated in rabbit papillary muscles driven at a rate of 0.5 or 2.0 Hz.2. When the frequency of stimulation was increased from 0.5 to 2.0 Hz, the log dose-response curve for the positive inotropic effect of epinine was displaced to the left, whereas the maximum of the developed tension was not changed.3. At both frequencies phentolamine (1 μmol/1) shifted the lower part of the log dose-response curve for epinine to the right, whereas pindolol (30 nmol/1) affected mainly the upper part. In the presence of both a- and β-adrenoceptor antagonists, the whole curve was shifted to the right in a parallel manner. However, cocaine (30 μmol/1) did not significantly influence the log dose-response curve of epinine.4. At 0.5 Hz a submaximal effective concentration of epinine (100 μmol/1) led to an approximately 100% increase of the cyclic AMP level after 60 s; the same increase of the cyclic AMP level was induced at 2.0 Hz by one-third the concentration of epinine (30 μmol/1).5. Phentolamine (1 μmol/1) did not affect the increase of the cyclic AMP level evoked by epinine, whereas pindolol (30 μmol/1) completely depressed it.6. The present results indicate that epinine produces its positive inotropic effect through direct stimulation of myocardial α-adrenoceptors as well as β-adrenoceptors, depending upon the concentration: in lower concentrations it acts mainly on α-adrenoceptors, whereas in higher concentrations it acts predominantly on β-adrenoceptors. The positive inotropic effect through α-adrenoceptor stimulation is mediated by cyclic AMP, while that through a-adrenoceptors is not.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1979.tb00006.x
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  • 3
    Electronic Resource
    Electronic Resource
    Frequency dependence of cyclic AMP in mammalian myocardium (1976)
    [s.l.] : Nature Publishing Group
    Nature 261 (1976), S. 716-717 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Experiments were carried out with papillary muscles isolated from the right ventricle of rabbits of both sexes (1.3?1.9 kg). Experimental methods were the same as previously reported5. The papillary muscles were mounted in a 20-ml organ bath containing Krebs?Henseleit solution (NaCl, 118mM; KCl, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/261716a0
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of Segontin and Reserpine on Isolated Medullary Granules (1965)
    [s.l.] : Nature Publishing Group
    Nature 205 (1965), S. 183-183 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The chromamn granules were prepared from suprarenal medulla of cattle as previously described5 and suspended in sucrose-phosphate buffer pH 6.8, The samples (7 ml.) were incubated for 60 min at 37 C under shaking. The granules of the incubated samples as well as of the non-incubated controls were ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/205183a0
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  • 5
    Electronic Resource
    Electronic Resource
    Release of Catechol Amines from Isolated Medullary Granules by Sympathomimetic Amines (1962)
    [s.l.] : Nature Publishing Group
    Nature 193 (1962), S. 890-891 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Since other sympathomimetic amines-phenyl-ethylamine, amphetamine, methamphet amine, and ephedrine - which are supposed to act like tyramine6 also release catechol amines from isolated chromaffin granules5, we investigated the effect of these amines on the catechol amine and the ATP content of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/193890a0
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of Ribonuclease on the Ribonucleic Acid, Adenosine Triphosphate and Catecholamine Content of Medullary Granules (1963)
    [s.l.] : Nature Publishing Group
    Nature 198 (1963), S. 795-796 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The chromaffin granules are prepared from suprarenal medulla of cattle (200 mg per sample) as previously described2 and suspended in isotonic sucrose sodium hydroxide solution pH 7-0. The samples contain in 5 ml. 2 ml. granules and 3 ml. sucrose sodium hydroxide solution pH. 7-0 with 0-1,800 jxg ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/198795a0
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  • 7
    Electronic Resource
    Electronic Resource
    Influence of temperature on the sensitivity of adrenergic β-receptors (1972)
    Springer
    Cellular and molecular life sciences 28 (1972), S. 1325-1326 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Versuche am Ileum des Kaninchens und der Trachea des Meerschweinchens mit dem Resorcinderivat Orciprenalin7 bei 25 bis 42°C führten zu folgenden Ergebnissen: Temperaturerhöhung verminderte am Ileum die Affinität des Orciprenalins, an der Trachea dagegen war sie ohne Einfluss8.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965324
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  • 8
    Electronic Resource
    Electronic Resource
    Freisetzung von Brenzcatechinaminen aus der isoliert durchströmten Nebenniere durch Tyramin und β-Phenyläthylamin (1961)
    Springer
    Cellular and molecular life sciences 17 (1961), S. 187-188 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary 1. When fresh cattle adrenals are perfusedin vitro with Tyrode's solution at 37°C, a spontaneous release of catechol amines takes place. This release is enhanced by the injection of tyramine or β-phenylethylamine. 2. In agreement with earlier observations on isolated medullary granules, β-phenylethylamine is more active than tyramine: 16 µM of β-phenylethylamine, 66 µM of tyramine, and 0.03 µM of acetylcholine release almost equal amounts of catechol amines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02160376
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  • 9
    Electronic Resource
    Electronic Resource
    Subzelluläre Verteilung der Brenzcatechinamine in Herz und Nebennieren von Meerschweinchen nach Vorbehandlung mitl-α-Methyl-Dopa (1966)
    Springer
    Cellular and molecular life sciences 22 (1966), S. 22-23 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary α-Methyl-noradrenalin synthesized after pretreatment of the guinea-pig with α-methyl-dopa was found to be localized, like noradrenalin, mainly in the granular fraction 100 000g of the heart and in the fraction of the chromaffin granules of the suprarenal medulla (15000 g). α-Methyl-adrenalin could not bo found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01897745
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  • 10
    Electronic Resource
    Electronic Resource
    Zur peripheren sympathikushemmenden Wirkung des Clonidins (1971)
    Springer
    Cellular and molecular life sciences 27 (1971), S. 70-71 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The influences of clonidine, tetracaine and procaine on the effects of electrical stimulation of the postganglionic sympathetic cardiac nerves have been compared in the isolated perfused rabbit heart. Much lower concentrations of clonidine than of tetracaine were necessary to antagonize the output of noradrenaline and the rise of frequency and contractility. Procaine even in the highest concentration tested did not inhibit the effects of nerve stimulation. In addition to its known central depression of sympathetic tone, clonidine exerts a specific inhibitory action on postganglionic sympathetic neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02137748
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