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  • K+ conductance  (2)
  • Lichen sclerosus et atrophicus  (2)
  • Life and Medical Sciences  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Amelanotic malignant melanoma of the vulva (1996)
    Springer
    Archives of gynecology and obstetrics 259 (1996), S. 45-50 
    Details
    ISSN: 1432-0711
    Keywords: Key words: Amelanotic melanoma ; Vulvar neoplasms ; Lichen sclerosus et atrophicus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We report on a 60 year old patient with a 6 month history of vulval pruritus and an erosive vulval lesion which was mistaken for lichen sclerosus et atrophicus. Histologically the diagnosis of an amelanotic malignant melanoma of the vulva was established. We review the literature about this rare malignant tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004040050134
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  • 2
    Electronic Resource
    Electronic Resource
    Amelanotisches Melanom der Vulva unter dem klinischen Bild eines „Lichen sclerosus et atrophicus“ (1996)
    Springer
    Der Hautarzt 47 (1996), S. 854-857 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Vulvaneoplasie ; Amelanotisches malignes Melanom ; Lichen sclerosus et atrophicus ; Key words Vulvar neoplasia ; Amelanotic malignant melanoma ; Lichen sclerosus et atrophicus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Malignant melanoma of the vulva is an uncommon disease. The amelanotic subtype is only rarely mentioned. We report a 60-year-old patient with a 6 month history of vulvar pruritus. Ivory lesions combined with erosions and fine `cigarette paper' – like wrinkling were suspicious for lichen sclerosus et atrophicus. Histologically the diagnosis of an amelanotic malignant melanoma was made. Amelanotic melanoma may present with a wide variety of clinical features. Even in the uncommon location of the vulva, amelanotic melanoma should be suspected in any nonhealing nonpigmented lesion.
    Notes: Zusammenfassung Das maligne Melanom der Vulva ist ein sehr seltener Tumor. Die amelanotische Variante ist nur in wenigen Fällen in der Literatur beschrieben. Wir berichten über eine 60jährige Patientin, die sich mit einer chronisch nässenden Vulvaläsion vorstellte. Die weißlichen Herde in Verbindung mit Erosionen und teilweise zigarettenpapierartiger Fältelung der Haut ließen klinisch v.a. an einen Lichen sclerosus et atrophicus denken. Histologisch zeigte sich ein amelanotisches malignes Melanom. Mit unserer Fallbeschreibung möchten wir ein weiteres Beispiel geben für die große morphologische Vielfalt des amelanotischen malignen Melanoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050520
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Chloride transport in the diluting segment of the K+ adapted frog kidney: Effect of amiloride and acidosis (1986)
    Springer
    Pflügers Archiv 407 (1986), S. S60 
    Details
    ISSN: 1432-2013
    Keywords: Amiloride ; Cl− transport ; Diluting segment ; K+ conductance ; Adaptation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The hypothesis was tested whether amiloride and/or an acute acid load influence Cl− transport in the diluting segment of the isolated-perfused kidney of the K+ adapted frog (rana pipiens). Transepithelial resistance (luminal cable analysis) and Cl− net flux (Cl− sensitive microelectrodes) were evaluated at various concentrations of amiloride, at highpCO2 or low HCO 3 − in the kidney perfusate. Amiloride or an acute acid load increase transepithelial resistance. The resistance-change at given concentrations of amiloride is markedly enhanced under static head conditions, i. e. at low luminal NaCl concentrations. Amiloride or acidosis (highpCO2) reduce Cl− net reabsorption; combination of both potentiates this inhibitory effect. We conclude: an acute acid load acidifies the cell cytosol. This effect is aggravated dramatically after amiloride-induced inhibition of the luminal Na+/H+ exchanger. The luminal pH-sensitive K+ conductance decreases. This results in a depolarization of the cell membranes. Consequently, the peritubular electrochemical driving force for the exit step of Cl− (from cell to blood) dissipates. Therefore, Cl− net reabsorption is blunted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584931
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Fused cells of frog proximal tubule: I. Basic membrane properties (1987)
    Springer
    The journal of membrane biology 100 (1987), S. 43-51 
    Details
    ISSN: 1432-1424
    Keywords: frog kidney ; proximal tubule ; HCO 3 − transport ; K+ conductance ; Cl− conductance ; fusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Proximal tubular cells of the frog (Rana esculenta) kidney were fused within an isolated tubule portion to giant cells according to the polyethylene-glycol fusion method. Cell membrane potentials (V m ) were measured while cells were superfused with varioús experimental solutions. Rapid concentration stepchanges of different ions allowed to calculate the respective transference numbers (t ion). In some experiments the specific cell membrane resistances (R m ) were evaluated by measuringV m induced by short current pulses injected into the cell with a second electrode. The experiments reveal: i) Fused cells of the proximal tubule exhibit aV m of −49.5±1.6 mV (n=65). ii) Addition of glucose to the perfusate yields a transient depolarization, consistent with a rheogenic Na/glucose cotransport system. iii) In absence of organic substrates the whole cell membrane conductance is made up of K+ and HCO3, iv) There is a positive relationship betweenV m andtK+ and a negative relationship betweenV m andtHCO 3 − . v) HCO 3 − -inducedV m changes are attenuated or abolished when Na+ is replaced with choline+, consistent with a rheogenic Na+/HCO 3 − cotransport system. vi) Replacement of Na+ by choline+ depolarizesV m and increasesR m by about 50%; addition of 3 mmol/liter Ba2+ to the Na+-free perfusate increasesR m by about 58% compared to the initial control value. vii) There is no measurable cell membrane Cl− conductance. We conclude that fused cells of proximal tubule exert both luminal and peritubular membrane properties. In absence of organic substrates the cell membrane potential is determined by the HCO 3 − and K+ transport systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02209139
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Immunological approach to the characterization of the outer acrosomal membrane of boar spermatozoa (1985)
    New York, NY : Wiley-Blackwell
    Gamete Research 11 (1985), S. 143-155 
    Details
    ISSN: 0148-7280
    Keywords: spermatozoa ; acrosomal membrane ; membrane antigens ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Antiserum to purified boar spermatozoan outer acrosomal membrane (OAM) was raised in rabbits and adsorbed with boar liver and serum glutaraldehyde cross-linked immunoadsorbents. The IgG fraction of the antiserum was purified by (NH4)2SO4 precipitation followed by ion-exchange chromatography. Indirect immunofluorescence showed bright fluorescent staining of the acrosomal cap of boar spermatozoa and to a lesser extent of the acrosomes of bull and goat spermatozoa after incubation with anti-OAM-IgG. Immuno-electron microscopy further confirmed the specificity of the antibody for the OAM. Preincubation of the anti-OAM-IgG with isolated OAM, completely abolished its reactivity. When tested by ELISA, anti-OAM-IgG reacted with boar, bull, goat, and human spermatozoa; however, its binding activity to boar spermatozoa was significantly greater as compared to spermatozoa from the other species tested.In an effort to identify OAM antigens recognized by this antiserum, the isolated boar OAM was labeled either with 3H or with 125I and solubilized by mild detergent treatment. The extracted components were immunoprecipitated with anti-OAM-IgG and protein A-bearing S. aureus and the thus isolated antigens were analysed on SDS-PAGE. The results suggest that anti-OAM-IgG recognized one high molecular 3H-labeled glycoprotein (270 kd), and four 125I-labeled polypeptides of lower molecular weight of the boar OAM.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1120110205
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  • 6
    Electronic Resource
    Electronic Resource
    Ultrastructural studies of the porcine zona pellucida during the solubilization process by Li-3,5-diiodosalicylate (1984)
    New York, NY : Wiley-Blackwell
    Gamete Research 9 (1984), S. 45-54 
    Details
    ISSN: 0148-7280
    Keywords: porcine zona pellucida ; solubilization ; Li-3,5-diiodosalicylate ; electron microscopy ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Isolated porcine zonae pellucidae were investigated using transmission electron microscopy. It was found that the fine structure of the zona is not homogenous. The region near the oocyte consists of a more tightly packed micellar structure than the structure near the external surface. However, no clear boundary between the two structural features could be detected. The assumption that the molecular structure of the external and internal surface of the zona is not the same is substantiated by the finding that antibodies against the whole zona structure react apparently only with the more loosely bound structure on the external surface. This effect is attributed to differences in the spacial arrangements of the micellar structures rather than to differences in chemical composition. Solubilization of the zona results in a reorientation of the otherwise randomly interconnected structure. At lower Li-3,5-diiodosalicylate concentration (0.05 M) the fibrils seems to expand so that the individual fibers lie almost parallel to each other. At a higher Li-3,5-diiodosalicylate concentration (0.2 M) the individual micelles begin to break up from the zona surface, while at a still higher concentration (0.3 M) the rigid structure of the zona is completely solubilized. In the latter case no residual material could be detected in the sediment following high speed centrifugation of the mixture. These electron microscopic results correlated with the protein concentrations in the supernatant indicating that the maximal protein content (35 ng/zona) is obtained at 0.3 M or higher Li-3,5-diiodosalicylate concentrations.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1120090105
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