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  • 1
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Analgodesierungsverfahren ; Ketamin ; Midazolam ; Pentazocin ; Key words Conscious sedation ; Ketamine ; Midazolam ; Pentazocine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Ketamine and midazolam, applied as intravenous medication for conscious sedation in day-case maxillo-facial surgery, has been proven to be superior to pentazocine and midazolam concerning cardiovascular parameters and respiratory depression. The aim of this study was to evaluate the effects of low-dose ketamine/midazolam on anxiety, analgesia, amnesia and subjective feelings. Methods. 140 out-patients (ASA I) were randomly divided into four groups. The double-blind study was prospective. Control group: Local anaesthesia (LA), articaine 4% plus epinephrine 1:200000 (n=35); test group P/M: LA, additional pentazocine 0.40 mg/kg bw and midazolam 0.075 mg/kg bw i.v. (n=35); test group K25/M: LA, additionally ketamine 0.25 mg/kg bw and midazolam 0.075 mg/kg bw i.v. (n=35), test group K50/M: LA, additionally ketamine 0.5 mg/kg bw and midazolam 0.075 mg/kg bw i.v. (n=35). LA was injected 3 min after application of the systemic medication in the test groups or application of a placebo (saline 0.9%) in the control group. Three further minutes later, operation was started. For evaluation questionnaires, visual analogue scales (VAS) and the state-trait anxiety inventory (STAI) were used. For testing retrograde and anterograde amnesia, acoustic sensations were delivered before application of the systemic medication (a Christmas carol) and during operation (the German national anthem). Results. The control group and the test groups were comparable with regard to biological data, duration of operation, applied dosage of local anaesthetics and actual anxiety before operation. The patients in all test groups rated intraoperative anxiety as mild, in contrast to the control group. Nearly no pain sensation during the operation was remembered in all test groups. Retrograde amnesia was not found in any group. Complete anterograde amnesia was observed in all test groups with respect to the intraoperative sensation, but even in the control group 50% of the patients did not remember having heard the national anthem. As subjective feelings negative criteria were mainly reported in the control group, where as in all test groups positive sensations dominated. Dreams were reported mostly after the higher dosage of ketamine, but no patient experienced any unpleasant dreams. The clinical assessment of the different regimes were excellent for test groups P/M and K50/M, modest for the control group and test group K25/M. Postoperatively, patients of test group P/M were remarkably sedated, but no clinically relevant sedation or motor weakness were observed in the other groups. Postoperative pain sensations were rated more intense in all test groups than in the control group. In test groups P/M and K25/M an increasing pain level was recorded during the postoperative period, with the consequence of a higher demand rate for analgesics. Conclusions. Dental surgery can be performed safely with low-dose ketamine/midazolam. Compared to pentazocine/midazolam, the higher dosage of ketamine (0.5 mg/kg bw) showed identical results intraoperatively, but was superior during the postoperative period (vigilance), and thus may represent a suitable dosage. The lower dosage of ketamine resulted in worse operating conditions, but a dosage higher than 0.5 mg/kg bw might lead to unconscious sedation and might increase the frequency of unpleasant dreams.
    Notes: Zusammenfassung Ketamin/Midazolam zur Analgosedierung erwies sich in bezug auf Kreislauf und Atmung gegenüber Pentazocin/Midazolam überlegen [23]. Diese Studie sollte klären, ob 0,25 oder 0,5 mg/kg KG Ketamin, 0,075 mg/kg KG Midazolam, unter den Aspekten Anxiolyse, Analgesie, Sedierung und Amnesie eine Alternative zu Pentazocin/Midazolam ist. Kontrollgruppe (KG): Lokalanästhesie (LA) mit Articain 4%/Adrenalinzusatz 1:200.000 (n=35); Testgruppe P/M: LA und 0,40 mg/kg KG Pentazocin/0,075 mg/kg KG Midazolam i.v. (n=35); Testgruppe K25/M: LA und 0,25 mg/kg KG Ketamin/0,075 mg/kg KG Midazolam i.v. (n=35); Testgruppe K50/M: LA und 0,50 mg/kg KG Ketamin/0,075 mg/kg KG Midazolam i.v. (n=35). Die LA wurde 3 min nach Analgosedierung injiziert. In den Testgruppen empfanden die Patienten intraoperativ nur geringe Angst und minimale Schmerzen. Negative Empfindungen wurden in der KG benannt, nicht in den Testgruppen. Träume (K50/M) hatten einen angenehmen Charakter. Operateur und Prüfer beurteilten Anästhesie, Kooperation und Gesamteindruck sehr gut in P/M und K50/M, schlechter in KG und K25/M. Postoperativ fiel in P/M eine stärkere Sedierung auf. Bei den postoperativen Schmerzen zeigte sich eine steigende Tendenz in den P/M und K25/M (Konsequenz: häufigere Analgetikaanforderungen). Midazolam/Ketamin ist für zahnärztlich-chirurgische Operationen geeignet: P/M und K50/M zeigten intraoperativ identische Ergebnisse, postoperativ sind K25/M und K50/M bezüglich der Vigilanz überlegen. Als ideale Dosierung von Ketamin können 0,5 mg/kg KG angesehen werden – 0,25 mg/kg KG verschlechtert die operativen Bedingungen – höhere Dosen könnten zu unerwünschten Nebenwirkungen führen.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 45 (1996), S. 923-930 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Airway-Management ; Schwierige Intubation ; Trachlight ; Transilluminationstechnik ; Key words Airway management ; Difficult intubation ; Light-guided intubation ; Trachlight®
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The technique of light-guided intubation is based on the principle that a source of light brought into the trachea results in clearly visible and defined transcutaneous illumination, while no illumination can be observed with the light source in the oesophagus (Fig. 1–7). The Trachlight® is a reintroduced instrument for this alternative intubation technique. The essential developments are: a length-adjustable stylet with a removable internal metal wire, a brighter light source, a stable handle with tight fixation of the endotracheal tube, and a time-dependent warning device to avoid extended intubations. One hundred twenty patients (Mallampati I, ASA I–III) were included in the study (conventional intubation [group KL, n=60], Trachlight® intubation [group TT, n=60]. The goals of the investigation were to examine the handling, application, problems, limitations, and possible indications of the method. The recorded parameters were: number of intubation attempts: course and duration of intubation; complications; and difficulties. In 40 patients (20 in each group) the indication for invasive blood presure measurement was given due to the surgical procedure, and circulatory parameters were recorded at defined moments during the intubation course. In group KL 55 patients were intubated in the attempt, 4 on the second, and 1 on the third (mean duration 23.6±10.4 s, range 12–60 s). Complications were: unilateral intubation (3 patients), bradycardia (2), asystole (1) and soft-tissue injury (1). Of the 60 patients in group TT, 54 were intubated successfully, the mean time needed being 29.9±14.8 s (range: 6–61 s). The remaining 6 were then intubated by the conventional method. Positive results in group TT included: easy handling and application, no injury to soft tissues or teeth, and invariably correct placement of the tube. Problems included: sufficient transillumination was achieved only after (entire) dimming of the room, insufficient control over the distal end of the tube due to an unfixed metal wire, unintentional switching off of the light while with-drawing the metal wire, difficulties in with-drawing the metal wire (too strong fixation), as well as disturbing effects of the warning device (blinking of the light 30 s after switching on). Reasons for the 6 intubation failures were introduction of the instrument into the oesophagus despite a supposed correct position, impossibility of correct placement in a patient with an extremely large goiter, and insufficiently clear transillumination in 3 extremely obese patients. The cardiovascular parameters showed no changes during laryngeal manipulation; a clear rise in heart rate and blood pressure was recorded, however, when the tube was inserted into the trachea. The cardiovascular parameters during conventional intubations were similar. The light-guided intubation technique can be regarded as a further alternative for airway management, due to the described improvements of the instrument. The indication for the technique is given in patients in whom no difficulty with intubation is expected, to avoid soft tissue damage and traumatising temporomandibular joint movements. Preclinical use may be limited due to environmental brightness. In patients with expected difficult airway management, fiberoptic intubation will remain the method of choice.
    Notes: Zusammenfassung Bei der Transilluminationstechnik führt eine Lichtquelle zur transkutanen Durchleuchtung im Larynxbereich. Das Trachlight ® ist ein hierfür neues Instrument mit wesentlichen Weiterentwicklungen: längenadaptierbares Führungsstilett mit innerem Metalldraht, hellere Lichtquelle, stabiler Handgriff mit Fixation des Tubus und Zeitautomatik zur Warnung vor zu langer Intubationsdauer. Das neue Instrument wurde randomisiert im Vergleich zur konventionellen Intubation eingesetzt (n=120). Meßparameter: Anzahl, Verlauf der Intubationsversuche und Komplikationen. Bei jeweils 20 Patienten wurden die Kreislaufparameter invasiv erfaßt. Mit dem Trachlight ® konnten 54 Patienten erfolgreich intubiert werden (Zeitbedarf 29,9±14,8 s [6–61 s]), konventionell 23,6±10,4 (12–60 s). Positiva: Einfache Handhabung, keine Verletzungen, korrekte Einführtiefe des Tubus. Probleme: Ausreichende Transillumination erst nach völliger Abdunkelung, unzureichende Kontrolle über distales Tubusende, unbeabsichtigtes Ausschalten der Lichtquelle, Schwierigkeiten beim Zurückziehen des Metalldrahts sowie Störung durch den Blinkmechanismus. Gründe für Intubationsversager: Einführung des Instruments in den Ösophagus trotz vermeintlich korrekter Position, Unmöglichkeit der Plazierung sowie unzureichende Transillumination. Die Kreislaufparameter zeigten in beiden Gruppen keine Veränderungen während der laryngealen Manipulation, jedoch einen deutlichen Anstieg beim Vorschieben des Tubus in die Trachea. Die Transilluminationstechnik kann als eine Alternative im Airway-Management bezeichnet werden. Im präklinischen Bereich ist sie problematisch, bei Patienten mit schwierigen Intubationsverhältnissen sollte der Fiberoptik der Vorzug gegeben werden.
    Type of Medium: Electronic Resource
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