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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 70 (1992), S. 520-528 
    ISSN: 1432-1440
    Keywords: Filiform polyposis ; Chronic inflammatory bowel disease ; Neuroendocrine system ; Crohn's disease ; Ulcerative colitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Filiform polyposis (FP) is a rare condition of uncertain pathogenesis, 28 cases of which have been published since it was first described in 1965. It is usually found in association with chronic inflammatory bowel disease, especially Crohn's disease and ulcerative colitis. The condition is characterized by the presence of numerous, densely packed, filiform polyps in the colon, which may resemble villous adenomas on endoscopy. We describe a case of FP occurring in a 33-year-old man with a 5-year history of Crohn's disease, in whom subtotal colectomy was performed because of perforation of the sigmoid colon. Microscopy revealed inflammatory pseudopolyps covered by largely normal and non-dysplastic colonic epithelium. The neuroendocrine system of the intestine in FP was investigated for the first time in this case: marked hyperplasia of endocrine cells immunoreactive for serotonin, somatostatin and enteroglucagon and of neural structures immunoreactive for substance P and vasoactive intestinal peptide was noted in the polyps and the adjacent intestinal mucosa. The patient has experienced no further complications in the 12 months since the operation. Medication administered in FP depends mainly on the nature of the underlying disease, and the amount of information published about this condition is as yet insufficient to allow any one specific type of treatment to be recommended. FP alone is not an indication for bowel resection but complications, such as massive haemorrhage or intestinal obstruction, may necessitate surgical intervention.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-0385
    Keywords: Key words: Adrenocortical deficiency ; Adrenal gland tuberculosis ; Addison's disease ; Tuberculosis. ; Schlüsselwörter: Nebennierenrindenunterfunktion ; Nebennierentuberkulose ; Morbus Addison ; Tuberkulose.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Die häufigste Ursache einer adrenocorticalen Insuffizienz (Morbus Addison) ist mit über 50 % die Autoimmunadrenalitis. Zu Anfang dieses Jahrhunderts war die Tuberkulose in 50–70 % der Fälle die Hauptursache. Die Tuberkulose spielt heute neben zahlreichen seltenen Ursachen mit etwa 10 % nur noch eine untergeordnete Rolle. Ein lediglich einseitiger Nebennierenbefall verläuft häufig asymptomatisch oder wie in der vorliegenden Kasuistik mit geringer bis mäßiger Symptomatik. Mit der Diagnose einer adrenocorticalen Insuffizienz ist die Frage nach der Ursache zunächst nicht geklärt. An der Beobachtung eines Patienten mit einer Nebennierentuberkulose werden die Probleme der Diagnosefindung und das therapeutische Vorgehen beschrieben und diskutiert.
    Notes: Summary. Adrenocortical insufficiency (Addison's disease) is a functional diagnosis. At the beginning of this century, tuberculosis was recognized as the main etiological cause (50–70 %). Today, however, tuberculosis represents only 10 % of the cases. Adrenocortical insufficiency is mainly caused by autoimmune adrenalitis (more than 50 %). Unilateral adrenocortical disease is usually asymptomatic or presents, as in the case described, with minor symptoms. This case report of adrenal tuberculosis illustrates the current challenges of diagnosis and therapy.
    Type of Medium: Electronic Resource
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