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  • Key words: Guinea pig — NK1 receptor antagonist — Substance P — Plasma exudation — Nasal allergy  (1)
  • Magnetic resonance imaging  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The effects of NK1 receptor antagonists (FK224 and FK888) on agonist- and antigen-induced nasal microvascular leakage in guinea pigs (1997)
    Springer
    Inflammation research 46 (1997), S. 28-31 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Guinea pig — NK1 receptor antagonist — Substance P — Plasma exudation — Nasal allergy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract.   Objective: To study the inhibitory effects of two NK1 receptor antagonists on substance P (SP) and antigen-induced increase of nasal vascular permeability in ovalbumen (OA)-sensitized guinea pigs. ¶Material: Male Dunkin-Hartley guinea pigs. ¶Treatment: SP (100 〈mu〉;mol/l), FK224 (1–10 〈mu〉 mol/kg) and FK888 (0.2– 2 〈mu〉mol/kg). ¶Methods: The in vivo model of nasal microvascular leakage was used for nasal allergic challenge in ovalbumin (OA)-sensitized guinea pigs, or nasal stimulation with substance P (SP) in non-sensitized animals. Nasal microvascular leakage was measured by the accumulation of Evans Blue dye after intravenous injection. ¶Results: Following nasal stimulation with SP 100 〈mu〉M, the concentration of dye in the nasal lavage fluid rapidly increased. NK1 receptor antagonists FK224 (10 〈mu〉mol/kg i.v.) and FK888 (2 〈mu〉mol/kg i.v.) inhibited SP-induced microvascular leakage. In OA-sensitized guinea pigs, exudation of dye into nasal lavage fluid was observed soon after topical antigenic stimulation and continued for over 60 min. Both NK1 receptor antagonists inhibited the immediate phase of the antigen-induced microvascular leakage. ¶Conclusions: We conclude that the immediate change of vascular permeability during the nasal allergic response is mediated by activation of the NK1 receptor in the guinea-pig.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050037
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  • 2
    Electronic Resource
    Electronic Resource
    Solitary fibrous tumor of the parotid gland extending to the parapharyngeal space (1998)
    Springer
    European archives of oto-rhino-laryngology and head & neck 255 (1998), S. 18-21 
    Details
    ISSN: 1434-4726
    Keywords: Key words Parotid gland ; Solitary fibrous tumor ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Solitary fibrous tumors (SFT) arise in the pleura and less commonly in extrapleural sites. Head and neck regions have included the nose and paranasal sinuses, soft palate, epiglottis, thyroid, parotid and submandibular glands, as well as the infratemporal fossa and parapharyngeal space. We report a case of SFT arising from the parotid gland and extending to the parapharyngeal space. To our knowledge, this is the fourth case of SFT originating from the parotid gland and is the largest of its kind among the extrapleural lesions described. The characteristics revealed by computed tomography and magnetic resonance imaging are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004050050015
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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