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  • Key words: Magnetic resonance imaging (MRI)  (1)
  • rat liver  (1)
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  • 1
    ISSN: 1432-1084
    Keywords: Key words: Magnetic resonance imaging (MRI) ; Interventional MRI ; Fibre optics ; Laser therapy ; MR-guided therapy ; Specialised MRI systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of this study was to develop methods of visualising optical fibres on MRI scans for monitoring interstitial laser therapy. Scans were performed on a specialised MRI extremity scanner at 0.17 T. Optical fibres of 0.4 mm diameter used for delivering laser energy were coated with iron particles from a superferromagnetic contrast agent. MR images of the fibres were acquired using gradient echo sequences (TR/TE = 300/10, 1 mm in-plane, 3 mm slice) and assessed for fibre visibility. Coated fibres could be resolved as lines 2 ± 1 mm wide using the gradient echo sequence. Uncoated fibres were invisible on the sequences used for in vivo therapy monitoring due to partial volume averaging. It is concluded that optical fibre visualisation by MRI may be improved by coating with ferromagnetic particles. Biocompatibility requires further assessment, but direct coating appears to be a promising method for fibre visualisation in MR-guided laser therapy.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Magnetic resonance materials in physics, biology and medicine 2 (1994), S. 299-302 
    ISSN: 1352-8661
    Keywords: MRI ; laser surgery ; ILP ; real-time ; rat liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics
    Notes: Abstract Magnetic resonance imaging (MRI) is showing considerable promise as a monitor for interventional procedures. Laser surgery is “MRI compatible, ” and temperature-sensitive imaging techniques can be usefully applied to these procedures. We have been investigatingT 1derived temperature-dependent imaging as a monitor for interstitial laser photocoagulation (ILP) in rat liver.In vitro experiments suggested that temperature calibration may be achieved. We have investigated ILPin vivo using short TR spin-echo imaging sequences taking one set of images every 30 s during and after the procedure. Our resultsin vivo suggest that this simple model may be inadequate for temperature mapping as the biological reaction to the ILP is on a similar time scale to that of the procedure. Nonetheless, MRI shows well-defined, repeatable signal changes that can be related to histological borders.
    Type of Medium: Electronic Resource
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