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  • Key words Secondary leukemia  (1)
  • MLL/AF4 rearrangement  (1)
  • Surgical management  (1)
  • 1
    ISSN: 1432-0584
    Keywords: Key words Secondary leukemia ; Translocation t(4;11) ; MLL/AF4 rearrangement ; PCR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Secondary acute myeloid leukemia occurring in a 15-year-old boy 11 years after initial treatment of a common lymphoblastic leukemia (c-ALL) is described. Initial complete remission was terminated after 4 years by an isolated testicular relapse, followed by first bone marrow relapse within 18 months. After he achieved remission again, an allogeneic bone marrow transplantation from his HLA-identical brother was performed. Five years and 9 months later, the patient developed thrombocytopenia, leukopenia, and anemia, but bone marrow biopsies at this time demonstrated only myelofibrosis, with no blast cell population present. A polymerase chain reaction assay of a peripheral blood sample recognized the mRNA fusion region for the MLL/AF4 rearrangement, i.e., the molecular equivalent of the translocation (4;11)(q21,q23). Four weeks later, a blast cell population with AML-M1 morphology according to the FAB classification appeared in the bone marrow, and translocation (4;11) was detected by cytogenetics. Thus, secondary leukemias with chromosomal 11q23 rearrangement can develop after a long latency period and can be diagnosed earlier with the PCR technique.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 379 (1994), S. 307-309 
    ISSN: 1435-2451
    Keywords: Benign pleural mesothelioma ; Localized ; Diagnosis ; Surgical management ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das benigne Pleuramesotheliom ist ein sehr seltener Tumor, für deren Ursprung die Mesothelien, aber auch das submesotheliale Bindegewebe diskutiert wird. Daher werden these Tumoren in der Literatur u. a. auch als Pleurafibrom, submesotheliales Fibrom, lokalisiertes fibröses Mesotheliom und monophasischer Spindelzelltumor beschrieben. Das Wachstum dieser Tumoren ist sehr langsam und geht über Jahre his Jahrzehnte. Im Gegensatz zum häufiger auftretenden malignen Pleuramesotheliom ist ein gehäuftes Auftreten nach Asbestex-position nicht zu beobachten. Wir berichten über eine 47jährige Patientin mit einem großen benignen Pleuramesotheliom im Bereich des rechten Thorax.
    Notes: Abstract Benign mesothelioma of the pleura is a very rare tumor. The cells responsible originate from either the mesothelium or the submesothelium. This is why such tumors are described in the literature as fibroma of the pleura, mesothelial fibroma, localized fibrous mesothelioma and monophasic spindle cell tumor. Their growth, is very slow taking several years or even decades. In contrast to the more common malignant mesothelioma of the pleura, it is not related to asbestos exposure. This report deals with a 47-year-old woman patient with a giant benign mesothelioma of the pleura in the region of the right thorax, which was completely removed by thoracotomy.
    Type of Medium: Electronic Resource
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