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  • 1
    Electronic Resource
    Electronic Resource
    Periorbitales Ödem als Initialsymptom eines Lupus erythematodes profundus (1999)
    Springer
    Der Hautarzt 50 (1999), S. 889-892 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Kollagenose ; Lupus erythematodes profundus ; Periorbitales Ödem ; Key words Collagenosis ; Lupus panniculitis ; Periorbital edema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Periorbital edema may occur initially or in the course of a wide variety of diseases. One of these diseases is lupus panniculitis, a variant of lupus erythematosus, characterized by firm subcutaneous nodules that may ulcerate with subsequent scar formation. We present a case of lupus panniculitis in which the periorbital edema was the initial manifestation. Knowledge about the differential diagnostic possibilities of periorbital edema as well as the different variants of cutaneous lupus erythematosus is important to reach the correct diagnosis.
    Notes: Zusammenfassung Das periorbitale Ödem ist ein Symptom, das initial oder im Verlauf von Erkrankungen verschiedenster Genese auftreten kann. Eine mögliche Assoziation stellt der Lupus erythematodes profundus dar. Diese Krankheit ist durch subkutane knotige und plattenartige Infiltrate gekennzeichnet, welche zu Ulzerationen und narbigen Einziehungen führen können. Anhand eines Fallberichts wird aufgezeigt, daß ein periorbitales Ödem als Initialsymptom den typischen Hautveränderungen eines Lupus erythematodes profundus vorausgehen kann. Die Kenntnis der möglichen Differentialdiagnosen bei periorbitalem Ödem sowie der unterschiedlichen Varianten eines Lupus erythematodes ist für die Diagnosestellung von entscheidender Bedeutung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050051005
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  • 2
    Electronic Resource
    Electronic Resource
    Althesin interaction with human plasma steroid binding globulins (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 181-185 
    Details
    ISSN: 1432-1041
    Keywords: althesin ; steroid binding globulins ; drug interaction ; steroid anaesthetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The binding affinities of two steroid anaesthetics, alphaxalone (Alfx) and alphadolone acetate (Alfd), for testosterone-oestradiol-binding globulin (TeBG) and corticosteroid-binding globulin (CBG) were measured in human serum. In 8 male patients, the effect of i.v. administration of Althesin (a mixture of Alfx and Alfd) on the transport of testosterone (T) and cortisol (F) was studied. Both Alfx and Alfd bind to TeBG and CBG with a relatively high affinity (106M−1). A significant change in the percentage of unbound T was observed during Althesin infusion, with no change in total T concentration or in the TeBG binding parameters. The results suggest that by interaction with TeBG binding sites Alfx and/or Alfd displaced T bound to TeBG, and transiently increased the percentage of unbound T. A significant increase in the concentration of F was observed during althesin infusion, while the percentage of unbound F and the CBG binding parameters were unchanged. The dose of Alfx and Alfd used was not sufficient to alter the transport of F during brief althesin anaesthesia in men.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547419
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    Paper (German National Licenses)
    Fulltext
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