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  • 1
    Electronic Resource
    Electronic Resource
    Inconsistency between severe substantia nigra degeneration with Lewy bodies and clinical parkinsonism in dementia patients: a cliniconeuropathological study (2000)
    Springer
    Acta neuropathologica 99 (2000), S. 511-516 
    Details
    ISSN: 1432-0533
    Keywords: Key words Dementia ; Parkinson’s disease ; Substantia nigra
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In a retrospective cliniconeuropathological study, we reviewed all the cases received in our dementia brain bank during a 4-year period to determine if all patients with severe substantia nigra (SN) degeneration and SN Lewy bodies (LBs) exhibited prominent signs of parkinsonism and were treated for parkinsonism during the disease course. The SN of 426 cases were graded for microscopic degeneration using a semiquantitative five-tiered scale, with grade 0 indicating normal and grade 4 the most severe degeneration. Twenty-nine cases with grade 3 (16) or grade 4 (13) SN degeneration with SN LBs and clinical records were identified. Ten had been treated for parkinsonism (6 grade 3, 4 grade 4) and 19 had not. Whereas most of the patients had exhibited signs of end-stage parkinsonism during their last year, 1 grade 3 and 2 grade 4 patients apparently never exhibited prominent signs of parkinsonism during the course of their dementia. No clear neuropathological differences were noted between these patients that did not have prominent signs and a control group of six patients with clinical Parkinson’s disease with dementia (parkinsonism onset at least 1 year before dementia onset). We conclude that in patients with dementia there is an inconsistent relationship between the expression of clinical parkinsonism during life and severe SN degeneration with LBs identified at necropsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051153
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  • 2
    Electronic Resource
    Electronic Resource
    Light, fluorescence, and electron microscopic features of neuronal intranuclear hyaline inclusions associated with multisystem atrophy (1980)
    Springer
    Acta neuropathologica 50 (1980), S. 115-120 
    Details
    ISSN: 1432-0533
    Keywords: Neuronal intranuclear hyaline inclusions ; Multisystem atrophy ; Autofluorescence and ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Light, fluorescence, and electron microscopic features of intranuclear hyaline inclusions of neurons associated with multisystem atrophy in a 21-year-old woman are described. The neuronal inclusions resemble Marinesco bodies on light microscopy but differ from the latter in their distribution, autofluorescence, and ultrastructure. They are widespread in almost all central, peripheral, and autonomic neurons and are generally larger than Marinesco bodies. The inclusions emit yellow-green autofluorescence with ultraviolet light between 470 and 530 nm of the spectrum and are ultrastructurally composed of haphazardly arranged, uniform, fine, straight filaments (8–9 nm in diameter). The neuronal inclusions have neither the ultrastructural feature of known viral inclusions nor are associated with virus particles. Their chemical nature and pathogenesis remain to be elucidated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00692861
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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