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  • 1
    Electronic Resource
    Electronic Resource
    Inconsistency between severe substantia nigra degeneration with Lewy bodies and clinical parkinsonism in dementia patients: a cliniconeuropathological study (2000)
    Springer
    Acta neuropathologica 99 (2000), S. 511-516 
    Details
    ISSN: 1432-0533
    Keywords: Key words Dementia ; Parkinson’s disease ; Substantia nigra
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In a retrospective cliniconeuropathological study, we reviewed all the cases received in our dementia brain bank during a 4-year period to determine if all patients with severe substantia nigra (SN) degeneration and SN Lewy bodies (LBs) exhibited prominent signs of parkinsonism and were treated for parkinsonism during the disease course. The SN of 426 cases were graded for microscopic degeneration using a semiquantitative five-tiered scale, with grade 0 indicating normal and grade 4 the most severe degeneration. Twenty-nine cases with grade 3 (16) or grade 4 (13) SN degeneration with SN LBs and clinical records were identified. Ten had been treated for parkinsonism (6 grade 3, 4 grade 4) and 19 had not. Whereas most of the patients had exhibited signs of end-stage parkinsonism during their last year, 1 grade 3 and 2 grade 4 patients apparently never exhibited prominent signs of parkinsonism during the course of their dementia. No clear neuropathological differences were noted between these patients that did not have prominent signs and a control group of six patients with clinical Parkinson’s disease with dementia (parkinsonism onset at least 1 year before dementia onset). We conclude that in patients with dementia there is an inconsistent relationship between the expression of clinical parkinsonism during life and severe SN degeneration with LBs identified at necropsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051153
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  • 2
    Electronic Resource
    Electronic Resource
    Light, fluorescence, and electron microscopic features of neuronal intranuclear hyaline inclusions associated with multisystem atrophy (1980)
    Springer
    Acta neuropathologica 50 (1980), S. 115-120 
    Details
    ISSN: 1432-0533
    Keywords: Neuronal intranuclear hyaline inclusions ; Multisystem atrophy ; Autofluorescence and ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Light, fluorescence, and electron microscopic features of intranuclear hyaline inclusions of neurons associated with multisystem atrophy in a 21-year-old woman are described. The neuronal inclusions resemble Marinesco bodies on light microscopy but differ from the latter in their distribution, autofluorescence, and ultrastructure. They are widespread in almost all central, peripheral, and autonomic neurons and are generally larger than Marinesco bodies. The inclusions emit yellow-green autofluorescence with ultraviolet light between 470 and 530 nm of the spectrum and are ultrastructurally composed of haphazardly arranged, uniform, fine, straight filaments (8–9 nm in diameter). The neuronal inclusions have neither the ultrastructural feature of known viral inclusions nor are associated with virus particles. Their chemical nature and pathogenesis remain to be elucidated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00692861
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Autonomic neurons of the sacral spinal cord in amyotrophic lateral sclerosis, anterior poliomyelitis and “neuronal intranuclear hyaline inclusion disease”: Distribution of sacral autonomic neurons (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 233-237 
    Details
    ISSN: 1432-0533
    Keywords: Autonomic neurons of sacral cord ; Selective vulnerability ; Degenerative disorders of neurons ; Vesicorectal function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Further evidence is presented that the Onuf's nucleus (or “colonne en torsade” of Laruelle) and the intermediolateral nucleus of the sacral cord share common selective vulnerability with the thoracolumbar intermediolateral nucleus in ALS, anterior poliomyelitis and “neuronal intranuclear hyaline inclusion disease”. Sparing of the sacral nuclei in the motor neuron diseases and neuronal loss of the nuclei in the multisystem atrophy are correlated well with normal and disturbed vesicorectal function. The clinicopathological evidence strongly supports the view that the Onuf's nucleus represents autonomic neurons much as the intermediolateral nucleus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690640
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Clinical parkinsonism in dementia patients with substantia nigra Lewy bodies (1999)
    Springer
    Journal of neural transmission 106 (1999), S. 47-57 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Lewy body disease ; parkinsonian syndrome ; substantia nigra.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. In a retrospective clinicopathological study, we examined the substantia nigra (SN) of 48 dementia patients with SN Lewy bodies (LBs) to determine if the severity of degeneration correlated with either the occurrence of signs of parkinsonism at dementia presentation or with the frequency of treatment for parkinsonism during the disease course. The SN specimens were graded for microscopic degeneration using a semi-quantitative five-tiered scale. Whereas no correlation was found between the grade of degeneration and occurrence of signs at presentation (r = −0.16, p = 0.18), with 16 of 38 patients having had signs reported, a more severe grade was statistically correlated with an increased frequency of treatment during the course (r = 0.41, p = 0.004), with ten of 41 patients having been treated for parkinsonism. Contrary to our expectations, we found that fewer than half of the patients with the two most severe grades of degeneration presented with signs of parkinsonism or were ever treated for parkinsonism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050140
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Universal drag reduction characteristics of saline water-soluble poly(ethylene oxide) in a rotating disk apparatus (2000)
    Springer
    Colloid & polymer science 278 (2000), S. 701-705 
    Details
    ISSN: 1435-1536
    Keywords: Key words Drag reduction ; Poly(ethylene oxide) ; Hydrodynamic volume ; Ocean thermal energy conversion ; Rotating disk flow ; Turbulence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  Polymer-induced turbulent drag reduction in a rotating disk apparatus was investigated using nonionic poly(ethylene oxide) (PEO) in a synthetic saline solution with novel application to ocean thermal energy conversion technology. A maximum total (skin friction plus form) drag reduction of 30% was obtained with 50 wppm of PEO with molecular weight 5.0 × 106. The concentration dependence of the percentage drag reduction for the PEO/saline solution system is found to fit Virk's empirical correlation, and a universal correlation for various molecular weights and Reynolds numbers is also presented. Furthermore, hydrodynamic volume fraction was introduced to correlate drag reduction efficiency with molecular parameters in this PEO/saline solution system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960000328
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    Paper (German National Licenses)
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