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  • 1
    Electronic Resource
    Electronic Resource
    “Tolerogenic effect” of the liver for a small bowel allograft (2000)
    Springer
    Transplant international 13 (2000), S. S123 
    Details
    ISSN: 1432-2277
    Keywords: Key words Liver transplantation ; Small bowel transplantation ; Tolerogenicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A newly developed liver/small bowel transplantation model (LSBTx) was used to investigate the tolerogenic effect of a liver allograft toward a simultaneously transplanted small bowel. Small bowel transplantation (SBTx) under high-dose immunosuppression was compared to LSBTx with a lower FK506 dosage. Syngeneic Lewis [(LEW) to LEW] and two fully allogeneic rat strain combinations (Brown Norway-to-LEW and Dark Agouti-to-LEW) were used. Clinical course and histological findings after SBTx demonstrated a chronic rejection of the small bowel allograft within 100 days. However, after LSBTx long-term acceptance (〉 150 days) was achieved after a transient rejection crisis, although initial immunosuppression was significantly lower. Furthermore, indicator heart transplantations demonstrated the induction of donor-specific tolerance in both allogeneic strain combinations. In contrast to other LSBTx rat models, these results reflect observations after human LSBTx, in which the rate of acute and chronic rejection is also significantly lower than after human SBTx.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050296
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Donor-derived alloantigen-presenting cells persist in the liver allograft during tolerance induction (2000)
    Springer
    Transplant international 13 (2000), S. 12-20 
    Details
    ISSN: 1432-2277
    Keywords: Key words Liver/small bowel transplantation ; Tolerance ; Dendritic cells ; Kupffer cells ; Antigen-presenting cells ; Chimerism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The predictive value of chimerism was evaluated in three different transplantation models in the rat without immunosuppression: small bowel- (SBTx), liver- (LTx), and liver/small bowel transplantation (LSBTx) were performed in the Brown Norway (BN)-to-Lewis- (LEW) strain combination. Immunohistochemistry and flow cytometry were used to identify donor cells in the recipient's spleen. Their number did not change significantly during transient rejection or tolerance after LTx and LSBTx. However, the amount of donor-derived nonparenchymal cells within the liver allograft including antigen-presenting cells (APCs), such as dendritic and Kupffer cells, clearly mirrored the recipient's immune status: as expected, their number decreased during rejection, but recovered considerably during and after tolerance induction. We conclude that donor cells in the periphery of the recipient correlate with the presence of the allograft, but do not seem to influence graft acceptance actively. However, the kinetics of the detected donor APC population in the liver suggests their important role in modifying the recipient's immune response towards tolerance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050002
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    391. Mikrochirurgische Modelle als Basis präklinischer Transplantationsforschung (1983)
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 924-924 
    Details
    ISSN: 1435-2451
    Keywords: Microsurgery ; Organ transplantation ; Mikrochirurgie ; Organtransplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Aufbauend auf Grundnahttechniken lassen sich mit optischen Hilfsmitteln und mikrochirurgischen Methoden größere Operationen an Ratten durchführen. Mit den mikrochirurgischen Modellen Gefäß-, Herz-, Dünndarm-, Niere-, Pankreas- und Lebertransplantation können mit Inzuchtstämmen grundsätzliche Phänomene wie Transplantatabstoßung (HVGR) bzw. Transplantat gegen Wirt Reaktion (GVHR) analysiert werden. Die Stärke dieser Reaktionen ist abhängig 1. vom Histoinkompatibilitätsgrad, 2. von der Menge des allogenen Gewebes, 3. von der Transplantatlokalistation und 4. von der Manipulation des Immunsystems von Spender und Empfänger. Die voll physiologischen orthotopen Modelle haben dabei die größte präklinische Relevanz.
    Notes: Summary Using simple suture technqiues as a basis, it is possible to carry out major operations in rats using microsurgical methods and magnifying glasses. The microsurgical models of vessels, heart, small intestine, kidney, pancreas and liver transplantation enable us to analyse graft rejection (HVGR) and graft versus host reaction (GVHR), expecially in inbred rat strains. The strength of these reactions is dependent upon 1. the degree of histo-incompatibility, 2. the quantity of allogeneic material, 3. the graft localization and 4. the immunological manipulation of donor and recipient. The physiological orthotopic models are of greatest preclinical relevance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276217
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    Paper (German National Licenses)
    Fulltext
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