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Digitale Medien

Clinical pharmacokinetics of suramin in patients with onchocerciasis (1998)

Chijioke, C. P. ; Umeh, R. E. ; Mbah, A. U. ; [weitere]

Springer

European journal of clinical pharmacology 54 (1998), S. 249-251

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ISSN: 1432-1041

Schlagwort(e): Key words Suramin ; Onchocerciasis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Abstract Objective: Ten male patients with onchocerciasis received six weekly infusions of suramin according to the WHO-recommended regimen. Results: In no case did the plasma concentration of suramin exceed 300 mg · l−1, and serious toxicity was not observed. The apparent volume of distribution (median 20.6 l) was comparable to that reported for patients with prostatic carcinoma. Elimination from patients with onchocerciasis was relatively slow (median plasma clearance 6.2 ml · h−1, median terminal elimination half-life 91.8 days). Conclusion: Microfilariae were eliminated in eight out of ten patients. Spontaneous nodule regression was noted in four patients.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s002280050454

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Digitale Medien

Ivermectin binds avidly to plasma proteins (1990)

Klotz, U. ; Ogbuokiri, J. E. ; Okonkwo, P. O.

Springer

European journal of clinical pharmacology 39 (1990), S. 607-608

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ISSN: 1432-1041

Schlagwort(e): ivermectin ; pharmacokinetics ; plasma protein binding

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary Human pharmacokinetic data on the new antiparasitic agent, ivermectin, are scanty. For the evaluation of its disposition a specific HPLC assay with sensitive fluorescence detection was developed. Applying equilibrium dialysis, plasma protein binding of ivermectin was measured in five healthy individuals and it averaged 93.2±4.4% (SD). Such strong binding should be taken into consideration, especially in patients with malnutrition or with diseases in which a decrease in plasma proteins and consequently a higher free fraction of ivermectin could be expected.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00316107

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