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  • Key words. Squamous cell carcinoma; invasion; matrix; metalloproteinase.  (1)
  • Recombinant DNA  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Coordinated regulation of type I and type III collagen production and mRNA levels of pro α1(I) and pro α2(I) collagen in cultured morphea fibroblasts (1987)
    Springer
    Archives of dermatological research 279 (1987), S. 154-160 
    Details
    ISSN: 1432-069X
    Keywords: Collagen ; Fibroblasts ; Scleroderma ; Recombinant DNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fibroblast cultures were started from affected and unaffacted skin areas of six patients with localized scleroderma in an active stage. The cell lines were studied for synthesis of procollagens and fibronectin by metabolic labeling with 3H-proline and for their contents of mRNAs for pro α1(I) and pro α2(I) collagen. For this purpose a cDNA clone for human pro α1(I) collagen mRNA was constructed. The clone was identified by restriction site mapping and hybridization to the specific mRNAs. All the scleroderma fibroblast lines produced increased amounts of type I and type III collagens and fibronectin during the early passages. The cell lines gradually reduced their elevated synthesis of collagen and fibronectin to normal or near normal levels by the tenth passage. The ratios of α1(I) and α2(I) chains and of type I and type III collagens, and the extent of type I procollagen processing, remained relatively unchanged in all the cultures. The cellular levels of type I procollagen mRNAs were increased in all the cells exhibiting an increased synthesis of collagen. The results suggest that in localized scleroderma the fibroblasts have undergone a coordinated activation of collagen synthesis at transcriptional level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00413250
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Matrix metalloproteinases in tumor invasion (2000)
    Springer
    Cellular and molecular life sciences 57 (2000), S. 5-15 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Squamous cell carcinoma; invasion; matrix; metalloproteinase.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Controlled degradation of extracellular matrix (ECM) is essential for the growth, invasion, and metastasis of malignant tumors, and for tumor-induced angiogenesis. Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases collectively capable of degrading essentially all ECM components and they apparently play an important role in all these aspects of tumor development. Furthermore, recent evidence suggests that MMPs also play a role in tumor cell survival. In this review, we discuss the current concept concerning the role of MMPs and their inhibitors in tumor invasion, as a basis for prognosis and targeted therapeutic intervention in cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000180050495
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    Paper (German National Licenses)
    Fulltext
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