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  • Keywords Lipoprotein lipase, obesity, Zucker rat, food deprivation, food intake, insulin, insulin resistance, β–adrenergic pathway, adipose tissue, skeletal muscle.  (1)
  • Leucocyte populations  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Abnormal insulin and β-adrenergic modulation of lipoprotein lipase during refeeding after prolonged fasting in the Zucker rat (2000)
    Springer
    Diabetologia 43 (2000), S. 866-874 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Lipoprotein lipase, obesity, Zucker rat, food deprivation, food intake, insulin, insulin resistance, β–adrenergic pathway, adipose tissue, skeletal muscle.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. To characterise the response of tissue lipoprotein lipase to refeeding after prolonged (24 h) fasting in lean and obese Zucker rats, and to verify whether lipoprotein lipase in obese rats is resistant to the short-term action of insulin and escapes modulation by the β-adrenergic pathway.¶Methods. Lean Fa/? and obese fa/fa male Zucker rats fasted for 24 h and refed at will. Lipoprotein lipase activity in adipose and muscle tissues was assessed in the freely fed and fasted states and at various times during refeeding, with or without β-adrenergic blockade (propranolol).¶Results. The 24-h fast erased the phenotype-related differences in insulinaemia and adipose lipoprotein lipase activity present in freely fed rats. Adipose lipoprotein lipase increased twofold in obese rats 1 h after refeeding, whereas no change occurred at that time in lean rats. Activity remained at that level for at least 6 h after refeeding in obese rats, whereas in lean animals it was increased fivefold after 6 h of refeeding. In muscle of obese rats, lipoprotein lipase decreased in response to refeeding, but paradoxically increased twofold in lean animals. Giving propranolol to lean rats before refeeding abolished the atypical response of muscle lipoprotein lipase to food intake and restored the early (1 h after refeeding) increase in adipose lipoprotein lipase but had no effect in obese rats.¶Conclusion/interpretation. Refeeding after prolonged fasting activates the β-adrenergic pathway in lean rats, which transiently counteracts insulin-mediated modulation of lipoprotein lipase. The β-adrenergic pathway is not activated by refeeding in adipose tissue and muscle of the obese Zucker rat. In the obese Zucker rat, the early modulation of adipose lipoprotein lipase activity is abnormal upon refeeding after prolonged fasting, suggesting short-term resistance to the action of insulin. [Diabetologia (2000) 43: 866–874]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051463
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Changes in blood leucocyte populations induced by acute maximal and chronic submaximal exercise (1990)
    Springer
    European journal of applied physiology 59 (1990), S. 435-442 
    Details
    ISSN: 1439-6327
    Keywords: Acute maximal exercise ; Chronic submaximal exercise ; Leucocyte populations ; Lymphocyte populations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Absolute (×103·mm−3) or relative (%) numbers of blood leucocyte types (monocytes, lymphocytes, neutrophils) and lymphocyte subsets (T11+, T4+, T8+, B1+, and NKH1+) reacting with specific monoclonal antibodies were determined at rest, immediately after maximal exercise on a treadmill, in six controls (C), and in six young cyclists before training (BT) and after 5 months of training (AT). Maximal exercise significantly increased the absolute number (mobilization) of virtually all the types of leucocytes and subsets of lymphocytes in C, BT and AT subjects. In these subjects mobilization of natural killer cells (NKH1+) and cytotoxic/suppressor T lymphocytes (T8+) was greater than mobilization of the other leucocyte types and lymphocyte subsets; however, maximal exercise induced no significant changes in the relative numbers of any leucocyte types and lymphocyte subsets, except in the case of T4+ lymphocytes in AT cyclists. Chronic submaximal exercise induced increased mobilization of neutrophils and decreased mobilization of lymphocytes during maximal exercise, except in the case of B lymphocytes (B1+) and NKH1+ cells, and decreases in the absolute and relative number of neutrophils at rest. It remains to be seen how these results can explain the modifications of leucocyte activities noted in vitro after isolated or chronic exercise.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02388625
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    Paper (German National Licenses)
    Fulltext
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