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  • Kindling  (1)
  • NMDA  (1)
  • Purkinje neuron/cerebellar slice/calcium/long-term depression/rebound  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Calcium requirement of long-term depression and rebound potentiation in cerebellar Purkinje neurons
    Amsterdam : Elsevier
    Seminars in Cell Biology 5 (1994), S. 243-250 
    Details
    ISSN: 1043-4682
    Keywords: Purkinje neuron/cerebellar slice/calcium/long-term depression/rebound
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/scel.1994.1030
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Hippocampal slices of kindled rats reveal calcium involvement in epileptogenesis (1985)
    Springer
    Experimental brain research 57 (1985), S. 404-407 
    Details
    ISSN: 1432-1106
    Keywords: Epileptogenesis ; Kindling ; Hippocampal slice ; Extracellular calcium ; Extracellular potassium ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Daily repeated tetanic electrical stimulation (kindling) of the brain may cause a long term enhancement of synaptic transmission and epileptiform activity of progressive severity and generalisation, eventually leading to spontaneous seizures. Evidence for a cellular mechanism underlying kindling has been obtained in vitro in slices from the hippocampus of kindled rats. A marked enhancement in extracellular calcium changes, induced by electrical stimulation or by iontophoresis of excitatory aminoacids was found in kindled tissue. This implies that changes in dendritic calcium conductances are involved in kindling epileptogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236547
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Voltage sensitivity of NMDA-receptor mediated postsynaptic currents (1990)
    Springer
    Experimental brain research 81 (1990), S. 209-212 
    Details
    ISSN: 1432-1106
    Keywords: NMDA ; Excitatory postsynaptic current ; Voltage sensitivity ; Patch clamp ; Thin hippocampal slice ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Patch-clamp techniques were used to record pharmacologically-isolated N-methyl-D-aspartate-mediated excitatory postsynaptic currents (NMDA-EPSCs) from dentate granule cells in thin rat hippocampal slices. Membrane voltage modulated these EPSCs in two ways. Firstly, depolarization from resting potential enhanced EPSC amplitudes, as expected for a voltage-dependent block by Mg2+ of synaptically activated NMDA receptor channels. Secondly, depolarization markedly prolonged the time course of decay of NMDA-EPSCs in normal and low extracellular Mg2+. Both mechanisms were complementary in establishing a strong dependence between membrane potential and the amount of charge, namely Ca2+, transferred through synaptically activated NMDA receptor channels, that presumably underlies induction of long-term potentiation in the hippocampus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00230117
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    Paper (German National Licenses)
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