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  • NADPH-diaphorase  (2)
  • Laterodorsal tegmental nucleus  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Nitric oxide synthase-containing projections to the ventrobasal thalamus in the rat (1999)
    Springer
    Anatomy and embryology 200 (1999), S. 265-281 
    Details
    ISSN: 1432-0568
    Keywords: Key words Retrograde axonal transport ; Somatosensory system ; Pedunculopontine nucleus ; Laterodorsal tegmental nucleus ; Cholinergic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Microiontophoretic studies of thalamic neurons suggests that nitric oxide (NO) plays an important role in mediating somatosensory transmission. The thalamus contains few nitric oxide synthase (NOS)-immunoreactive neurons; thus, the major source of thalamic NO is presumably from NOS-positive axons of extrathalamic origin. The cells of origin of these putative NOS-containing pathways to the ventrobasal thalamus were investigated in rats by combining retrograde tracing with immunocytochemistry for NOS. The location and morphology of double-labeled neurons was compared with that of single-labeled neurons. The most significant sources of NOS-containing afferents to the thalamus were found to be the pedunculopontine (PPN) and laterodorsal tegmental (LDT) nuclei. NOS-immunoreactive neurons in these cholinergic nuclei project bilaterally to the thalamus, most strongly ipsilaterally. The thalamus appears to be a major target of PPN, since even selective thalamic injections result in retrograde labeling of at least one third of its NOS-immunoreactive neurons. A significant number of NOS-negative neurons in both the PPN and LDT also project to the thalamus. Minor sources of NOS-containing thalamic afferents include the lateral hypothalamus, the dorsal, median and pontine raphe nuclei, the parabrachial nuclei, and the pontomedullary reticular formation. In all these structures, NOS-negative thalamopetal neurons greatly outnumber the NOS-positive ones. Ascending sensory pathways to the thalamus, including those from the sensory trigeminal nuclei, the dorsal column nuclei, and the spinal cord, as well as the auditory and vestibular centers, arise exclusively from NOS-negative neurons. The major NOS-positive projections are implicated in affective and alerting systems, supporting that NO may act to modulate attentiveness in thalamic relay nuclei.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004290050278
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Nitric oxide nerves in the uterus are parasympathetic, sensory, and contain neuropeptides (1995)
    Springer
    Cell & tissue research 279 (1995), S. 339-349 
    Details
    ISSN: 1432-0878
    Keywords: Uterus ; Neuropeptides ; Autonomic ganglia ; Sensory ganglia ; NADPH-diaphorase ; Rat (Sprague Dawley)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Nitric oxide (NO) is synthesized in neurons and is a potent relaxor of vascular and nonvascular smooth muscle. The uterus contains abundant NO-synthesizing nerves which could be autonomic and/or sensory. This study was undertaken to determine: 1) the source(s) of NO-synthesizing nerves in the rat uterus and 2) what other neuropeptides or transmitter markers might coexist with NO in these nerves. Retrograde axonal tracing, utilizing Fluorogold injected into the uterine cervix, was employed for identifying sources of uterine-projecting neurons. NO-synthesizing nerves were visualized by staining for nicotinamide adenine dinucleotide phosphate (reduced)-diaphorase (NADPH-d) and immunostaining with an antibody against neuronal/type I NO synthase (NOS). NADPH-d-positive perikarya and terminal fibers were NOS-immunoreactive (-I). Some NOS-I/NADPH-d-positive nerves in the uterus are parasympathetic and originate from neurons in the pelvic paracervical ganglia (PG) and some are sensory and originate from neurons in thoracic, lumbar, and sacral dorsal root ganglia. No evidence for NOS-I/NADPH-d-positive sympathetic nerves in the uterus was obtained. Furthermore, double immunostaining revealed that in parasympathetic neurons, NO-I/NADPH-d-reactivity coexists with vasoactive intestinal polypeptide, neuropeptide Y, and acetylcholinesterase and in sensory nerves, NOS-I/NADPH-d-reactivity coexists with calcitonin generelated peptide and substance P. In addition, tyrosine hydroxylase(TH)-I neurons of the PG do not contain NOS-I/NADPH-d-reactivity, but some TH-I neurons are apposed by NOS-I varicosities. These results suggest NO-synthesizing nerves in the uterus are autonomic and sensory, and could play significant roles, possibly in conjunction with other putative transmitter agents, in the control of uterine myometrium and vasculature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318490
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Nitric oxide nerves in the uterus are parasympathetic, sensory, and contain neuropeptides (1995)
    Springer
    Cell & tissue research 279 (1995), S. 339-349 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Uterus ; Neuropeptides ; Autonomic ganglia ; Sensory ganglia ; NADPH-diaphorase ; Rat (Sprague Dawley)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Nitric oxide (NO) is synthesized in neurons and is a potent relaxor of vascular and nonvascular smooth muscle. The uterus contains abundant NO-synthesizing nerves which could be autonomic and/or sensory. This study was undertaken to determine: 1) the source(s) of NO-synthesizing nerves in the rat uterus and 2) what other neuropeptides or transmitter markers might coexist with NO in these nerves. Retrograde axonal tracing, utilizing Fluorogold injected into the uterine cervix, was employed for identifying sources of uterine-projecting neurons. NO-synthesizing nerves were visualized by staining for nicotinamide adenine dinucleotide phosphate (reduced)-diaphorase (NADPH-d) and immunostaining with an antibody against neuronal/type I NO synthase (NOS). NADPH-d-positive perikarya and terminal fibers were NOS-immunoreactive (-I). Some NOS-I/NADPH-d-positive nerves in the uterus are parasympathetic and originate from neurons in the pelvic paracervical ganglia (PG) and some are sensory and originate from neurons in thoracic, lumbar, and sacral dorsal root ganglia. No evidence for NOS-I/NADPH-d-positive sympathetic nerves in the uterus was obtained. Furthermore, double immunostaining revealed that in parasympathetic neurons, NOS-I/NADPH-d-reactivity coexists with vasoactive intestinal polypeptide, neuropeptide Y, and acetylcholinesterase and in sensory nerves, NOS-I/NADPH-d-reactivity coexists with calcitonin gene- related peptide and substance P. In addition, tyrosine hydroxylase(TH)-I neurons of the PG do not contain NOS-I/NADPH-d-reactivity, but some TH-I neurons are apposed by NOS-I varicosities. These results suggest NO-synthesizing nerves in the uterus are autonomic and sensory, and could play significant roles, possibly in conjunction with other putative transmitter agents, in the control of uterine myometrium and vasculature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410050289
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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