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  • Leucodystrophy  (1)
  • Nervous System  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 29 (1974), S. 127-138 
    ISSN: 1432-0533
    Keywords: Leucodystrophy ; Myelin ; Cattle ; Oligodendrocyte ; Node of Ranvier
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pathology of a recently recognised progressive disorder of myelin in mature Charolais cattle is described. Clinical signs are first noticed at 8–24 months of age and progress from slight ataxia to recumbency over a period of 1–2 years. Lesions are microscopic and restricted to the white matter of the central nervous system. They are most marked in the internal capsule, cerebellar white matter and spinal cord and consist of multiple eosinophilic plaques. Ultrastructurally the lesions are associated with the nodal region of the myelin sheath. They are composed of disordered myelin, hypertrophied and hyperplastic oligodendrocytic tongues and many small processes which originate from these. There is evidence of myelin breakdown, but this does not elicit a phagocytic response. The aetiology of this condition is not known but the nature of the pathological process suggests a basic derangement of the myelin bearing cell.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 11 (1968), S. 294-300 
    ISSN: 1432-0533
    Keywords: Nervous System ; Swayback ; White Matter ; Demyelination ; Spinal Cord
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Veränderungen in der Feinstruktur des Axons und der Myelinscheide der weißen Substanz des Rückenmarks an bei “Swayback” (enzootischer Ataxie) erkrankten Lämmern werden dargestellt. Einer fortschreitenden Degeneration des Axons folgen Veränderungen in der Myelinscheide. Die Auffassung von “Swayback” als einer ursprünglichen Erkrankung des Neuriten wird im Zusammenhang mit früheren Arbeiten besprochen. Die Hypothese wird aufgestellt, daß das Neuron infolge von Cytochromoxydaseverarmung und Kupfermangel unfähig ist, sein weiter entferntes peripheres Cytoplasma während des Wachstums zu erhalten, und daß Tätigkeit und funktionelle Belastungen zu irreversiblen Veränderungen in der Nervenzelle führen.
    Notes: Summary The alterations in the fine structure of the axon and myelin sheath in the white matter of the spinal cord of lambs affected with swayback are presented. A progressive degeneration of the axon is followed by changes in the myelin sheath. The concept of swayback as primarily a disease of the neurite is discussed in relation to previous work. The hypothesis is advanced that the neuron is unable to sustain its more distant peripheral cytoplasm during growth and that function and functional stresses may lead to irreversible changes in the nerve cell.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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