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  • Mus musculus  (5)
  • Life and Medical Sciences  (4)
  • Male subjects  (2)
  • 1
    Electronic Resource
    Electronic Resource
    The effect of graded immersion on heart volume, central venous pressure, pulmonary blood distribution, and heart rate in man (1978)
    Springer
    Pflügers Archiv 374 (1978), S. 115-118 
    Details
    ISSN: 1432-2013
    Keywords: Immersion ; Heart volume ; Pulmonary blood distribution ; Male subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present experiments have been conducted to study the immediate effects of graded immersion on the central circulation. When taking heart volume as an indicator, it was found that immersion to the diaphragm of a standing subject produces the same changes as assumption of the supine posture. Heart volume increases by approximately 130ml. When the water level is raised to the neck, an extra pressure corresponding to a water column extending from the diaphragm to the surface of the water of approximately 25 cm H2O forces blood into the thorax. The heart becomes distended by an additional 120ml. Correspondingly the central venous pressure at the height of the right atrium increases from 2.5 to 12.8 mm Hg when the water level rises from the diaphragm to the neck. The greater filling of the pulmonary circulation is accompanied by a decrease in vital capacity and visualized by scintigrams. The preferential increase in blood volume of the apical regions is striking. When raising the water level from the symphysis to the xiphoid heart rate falls by about 15%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00581289
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  • 2
    Electronic Resource
    Electronic Resource
    Time course of cardiac distension with rapid immersion in a thermo-neutral bath (1978)
    Springer
    Pflügers Archiv 374 (1978), S. 119-120 
    Details
    ISSN: 1432-2013
    Keywords: Heart size ; Central venous pressure ; Immersion ; Male subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 13 subjects standing in a narrow upright tank were exposed to rapid water immersion up to the neck. The tank was filled from an elevated reservoir in less than 4 s. In 8 subjects heart size was measured by Roentgen-cinematography combined with video tape recording. Planimetry of the diastolic postero-anterior area of the heart showed an average increase in heart size of 30% within 6 s. In 5 subjects central venous pressure and the height of hydrostatic pressure in the tank were recorded. The two pressures rose and fell simultaneously without delay when the hydrostatic pressure exceeded the level of the diaphragm. Rapid immersion caused a fall in heart rate of approximately 20%. The findings speak in favor of the concept that the right heart does not constitute a resistance and that the pulmonary circulation and the systemic capacitance vessels form a functional unit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00581290
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  • 3
    Electronic Resource
    Electronic Resource
    Esterase-16 (Es-16): Characterization, polymorphism, and linkage to chromosome 3 of a kidney esterase locus of the house mouse (1981)
    Springer
    Biochemical genetics 19 (1981), S. 1091-1099 
    Details
    ISSN: 1573-4927
    Keywords: Mus musculus ; esterase ; Es-16 ; Chr. 3
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A polymorphism for an isozyme of a presumed arylesterase, esterase-16 (EC 3.1.1.2), has been detected in kidney, heart, and spleen of the house mouse, Mus musculus, by means of isoelectric focusing and by disc electrophoresis. Three phenotypes can be distinguished: the ES-16A phenotype (IEP 5.9) was found in C57BL/10Sn and many other laboratory inbred strains; the ES-16B phenotype (IEP 6.1) was found in M. m. molossinus; and the ES-16C phenotype (IEP 5.9; very weak activity) was found in Peru-Coppock. Esterase-16 is strongly inhibited by 10−3 m p-chloromercuribenzoate, but not by 2·10−4 m bis-p-nitrophenyl phosphate or by 10−3 m Diamox. It stains well with indoxyl acetate and other indigogenic substrates but only weakly with α-naphthyl acetate. Esterase-16 is completely insoluble in water. It is apparently governed by a structural gene locus, Es-16, with three alleles, Es-16 a , Es-16b, and Es-16 c, respectively. Es-16 is closely linked to Car-1 and Car-2 on chromosome 3. Typing of 94 animals of the backcross (C57BL/10Sn × M. m. mol.) F1 × M. m. mol. revealed a recombination frequency of 8.51±2.9%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00484567
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  • 4
    Electronic Resource
    Electronic Resource
    Esterase-18 (ES-18) of the house mouse (Mus musculus): Biochemical characterization and genetics of an allozyme system linked to chromosome 19 (1988)
    Springer
    Biochemical genetics 26 (1988), S. 617-629 
    Details
    ISSN: 1573-4927
    Keywords: Mus musculus ; esterase-18 ; allozymes ; chromosome 19 ; gene order
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract This study describes the biochemical characterization, genetic variation, and linkage of a codominantly inherited murine esterase, termed ES-18. The enzyme was identified by isoelectric focusing of supernatants obtained after centrifugation of tissue homogenates and subsequent staining for esterase using either α-naphthyl acetate or 4-methylumbelliferyl elaidate as substrate. ES-18 exhibited an organ-specific variation of the intensity pattern of bands as seen in kidney, spleen, and macrophages, respectively. Its activity was highly sensitive to inhibition by 1 mmol · liter−1 p-chloromercuriphenyl-sulfonate but was resistant to bis-p-nitrophenyl phosphate. Four allozymes could be distinguished in kidney supernatants obtained from the inbred strains C57BL/10Sn (ES-18A), MOLF/Ei (ES-18B), WLL/BrA (ES-18C), and CAST/Ei (ES-18D). The enzyme is shown to be controlled by a structural locus,Es-18, which resides on chromosome 19. The gene orderLy-1—Got-1—4.7±1.6—Es-18 is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553784
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  • 5
    Electronic Resource
    Electronic Resource
    Esr, a second locus in the house mouse controlling esterase-5 (1982)
    Springer
    Biochemical genetics 20 (1982), S. 351-358 
    Details
    ISSN: 1573-4927
    Keywords: Mus musculus ; esterase-5 ; Esr locus ; chromosome 6
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Electrophoretic variation characterized by the presence (ES-5B+) or absence (ES-5B−) of esterase-5B in the plasma of the house mouse has been observed. It is suggested that the expression of esterase-5B is controlled by an autosomal locus, Esr, linked to Ldr-1 on chromosome 6, in addition to the presumptive structural locus Es-5, which is located on chromosome 8. A gene order of Lyt-3-Esr-Ldr-1 was determined by two crosses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00484429
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  • 6
    Electronic Resource
    Electronic Resource
    Esterase-18 (ES-18) of the house mouse (Mus musculus): Biochemical characterization and genetics of an allozyme system linked to chromosome 19 (1988)
    Springer
    Biochemical genetics 26 (1988), S. 617-629 
    Details
    ISSN: 1573-4927
    Keywords: Mus musculus ; esterase-18 ; allozymes ; chromosome 19 ; gene order
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract This study describes the biochemical characterization, genetic variation, and linkage of a codominantly inherited murine esterase, termed ES-18. The enzyme was identified by isoelectric focusing of supernatants obtained after centrifugation of tissue homogenates and subsequent staining for esterase using either α-naphthyl acetate or 4-methylumbelliferyl elaidate as substrate. ES-18 exhibited an organ-specific variation of the intensity pattern of bands as seen in kidney, spleen, and macrophages, respectively. Its activity was highly sensitive to inhibition by 1 mmol · liter−1 p-chloromercuriphenyl-sulfonate but was resistant to bis-p-nitrophenyl phosphate. Four allozymes could be distinguished in kidney supernatants obtained from the inbred strains C57BL/10Sn (ES-18A), MOLF/Ei (ES-18B), WLL/BrA (ES-18C), and CAST/Ei (ES-18D). The enzyme is shown to be controlled by a structural locus,Es-18, which resides on chromosome 19. The gene orderLy-1—Got-1—4.7±1.6—Es-18 is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02399606
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  • 7
    Electronic Resource
    Electronic Resource
    Esterase-23 (ES-23): Characterization of a new carboxylesterase isozyme (EC 3.1.1.1) of the house mouse, genetically linked to ES-2 on chromosome 8 (1984)
    Springer
    Biochemical genetics 22 (1984), S. 769-782 
    Details
    ISSN: 1573-4927
    Keywords: Mus musculus ; esterase ; temporal locus ; chromosome 8
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Genetic variation of a carboxylesterase isozyme (EC 3.1.1.1) of the house mouse, designated ES-23, is described. ES-23 was found in kidney, liver, and intestine. The isozyme was resistant to inhibition by 10−3 mol/liter eserine and was stained using α-naphthyl butyrate or 5-bromoindoxyl acetate as substrate. Five different phenotypes, ES-23A to ES-23E, could be distinguished by disc electrophoresis and by isoelectric focusing. ES-23 is controlled by a structural locus situated within the esterase gene cluster 2 on chromosome 8. An analysis of allele distribution among different strains suggested a separate structural locus for the isozyme, ES-23e, which is closely linked to the loci Es-2, Es-5, Es-7, and Es-11. Of the five phenotypes, only ES-23B was expressed in lung. This variation is apparently controlled by a cis-acting regulatory element, presumably a temporal locus, Es-23t, closely linked to the presumed structural locus Es-23e.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499472
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  • 8
    Electronic Resource
    Electronic Resource
    Stability of division-related protein and nucleic acid fractions in synchronized Tetrahymena (1967)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 70 (1967), S. 265-273 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The kinetics of RNA synthesis have been studied under various growth conditions using synchronized Tetrahymena pyriformis GL. The curves obtained are approximately linear in growth-supporting media but vary under other circumstances. The presence of amino acids in the medium stimulates RNA synthesis in Tetrahymena as it does in bacteria. Since these induced variations do not influence the essential features of the pre-cytokinetic period it is inferred that fluctuations in the rate of RNA synthesis described by others are probably not essential features of temperature-induced synchrony. In addition, the translational stability of division-related templates at synchronizing temperatures has been investigated. The synthesis of proteins necessary for cytokinesis is shown to be greatly reduced under conditions simulating a heat-shock. Inhibitor studies using cycloheximide indicate that protein synthesis is required longer into the cytokinetic phase than had previously been thought. Collectively the data are all compatible with the hypothesis that synthesis of division-related proteins is drastically reduced in heat-shocked Tetrahymena and that the basis for this reduction is hydrolysis of template RNA without concurrent translation.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040700306
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  • 9
    Electronic Resource
    Electronic Resource
    Temperature dependent RNA decay in TetrahymenaSupported by grant GM 06461-07 from the United States Public Health Service. (1966)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 68 (1966), S. 203-205 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040680215
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of temperature on the activity of ribonuclease from Tetrahymena pyriformisThis investigation was supported in part by U.S.P.H.S. training grant 5-T1-P-07 and by U.S.P.H.S. Research grant GM-06461-06. (1966)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 68 (1966), S. 95-97 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Intracellular ribonuclease from the ciliate Tetrahymena pyriformis GL was purified 10-fold. After preheating for 20 minutes at 100°C of the ribonuclease preparation 80% of its activity was lost. Preheating under the same conditions, however, in the presence of RNA, did not affect the enzyme activity. Between 0°C and 41°C the apparent activation energy was 15,600 cal per deg. per mole.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040680114
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