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  • 1
    Electronic Resource
    Electronic Resource
    Characteristics of in vitro ribonucleic acid synthesis by macronuclei of Tetrahymena pyriformis (1970)
    s.l. : American Chemical Society
    Biochemistry 9 (1970), S. 3947-3959 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00822a013
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  • 2
    Electronic Resource
    Electronic Resource
    Do Synchronizing Temperature Shifts Inhibit RNA Synthesis in Tetrahymena pyriformis? (1970)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 17 (1970), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: SYNOPSIS The effects of synchronizing temperatures on RNA metabolism in 2 strains of Tetrahymena pyriformis have been studied. High temperature shifts cause degradation of unstable RNA fractions, including whole cell RNA and nuclear RNA. The evidence indicates that this hydrolysis results in a net loss of unstable RNA during each temperature shift and, indirectly, to an inhibition of uptake2 of extra-cellular RNA precursors. The destruction of unstable RNA appears random; no evidence for stable template pools was found. In addition, both indirect in vivo and direct in vitro assays of RNA polymerase activity failed to reveal any inhibition by synchronizing heat shifts. The inhibition of precursor incorporation in vivo apparently stems from a lag in the uptake of label into the intracellular nucleotide pools. The temperature values required to induce net hydrolysis of unstable RNA correlate well with those required for synchronization for each strain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1970.tb04712.x
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  • 3
    Electronic Resource
    Electronic Resource
    Carrier-dependent and carrier-independent transport of anti-cancer alkylating agents (1981)
    [s.l.] : Nature Publishing Group
    Nature 294 (1981), S. 281-283 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] An assay which uses the mitogen phytohaemagglutinin (PHA) to induce proliferation in tissue culture of human peripheral T lymphocytes7"9 was developed for these experiments10. It can be seen (Fig. 1) that 3H-thymidine uptake was very low before PHA stimulation but increased steadily (as measured by ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/294281a0
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of methylated xanthines on mammalian cells treated with bifunctional alkylating agents (1980)
    [s.l.] : Nature Publishing Group
    Nature 285 (1980), S. 326-329 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The effects of caffeine on damaged human cells are less consistent than those on rodent cells16,21-24. Figure 1 shows the survival curves obtained when human HT-29 cells (ref. 25, human karyotype confirmed by K. Benirschke) were exposed to increasing concentrations of HN2 with or without a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/285326a0
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  • 5
    Electronic Resource
    Electronic Resource
    Bonding of Small Molecules to DNA following Ionizing Radiation (1970)
    [s.l.] : Nature Publishing Group
    Nature 225 (1970), S. 859-860 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have used both purified commercial calf thymus DNA (Calbiochem) and DNA purified from Tetrahymena pyriformis12. To demonstrate the formation of stable bonds after irradiation, DNA solutions containing labelled small molecules were irradiated in 2?3 mm depths using the electron beam of a Varian ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/225859a0
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  • 6
    Electronic Resource
    Electronic Resource
    Antibody-dependent cellular cytotoxicity-mediated serotherapy against murine neuroblastoma (1983)
    Springer
    Cancer immunology immunotherapy 15 (1983), S. 59-62 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Human peripheral lymphocytes (HLc) have been studied in vitro as possible effector cells in an antibody-dependent cellular cytotoxicity (ADCC) reaction. HLc were found to be active against murine neuroblastoma cells (MNB) inoculated into the flank of syngeneic mice. Both the time of onset of tumor appearance and the mean survival time of tumor-bearing host mice were beneficially influenced. Occasional animals could be cured of up to 105 tumor cells (1–10 cells of MNB are lethal). This level of tumor cytotoxicity approaches that of tolerance-dose chemotherapy and is without demonstrable side-effects. HLc from patients who had just received = 3,000 rads fractionated therapeutic X-irradiation were equally effective as HLc from control non-irradiated donors when assayed at equivalent HLc : tumor cell ratios. HLc could also inhibit MNB tumor cell growth in the ascitic form, confirming in vivo activity. Overall, HLc appeared almost as active as rat spleen cells in mediating a useful anti-tumor ADCC. This approach may ultimately prove useful in man, especially in the peritoneal cavity, and is currently limited only by the need to develop appropriate antisera. It is proposed and emphasized that such antisera need not necessarily be directed at tumor-specific antigens. Organ-specific antibodies such are already known to develop spontaneously in some human auto-immune diseases might be equally useful and are a naturally occurring potential source of appropriately expressed genetic material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00199463
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  • 7
    Electronic Resource
    Electronic Resource
    Murine neuroblastoma cured in vivo by an antibody-dependent cellular cytotoxicity reaction (1976)
    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 783-785 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table I In vitro AC 〉CC agai nst MNB \ cells 51Cr % Specific Sample c.p.m. ±s.e. release MNB cells, control 1140 38 0 MNBcells+RSC 1055 81 0 MNB cells, freeze-thawed 2019 55 100 MNB cells -f AS 1 :50f RSC 1528 34 44 MNB cells + AS 1 :250+RSC 1570 44 49 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/264783a0
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  • 8
    Electronic Resource
    Electronic Resource
    Non-coordinate Synthesis of Division-related m RNA (1968)
    [s.l.] : Nature Publishing Group
    Nature 218 (1968), S. 1271-1273 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Tetrahymena pyriformis GL was grown and synchronized in a media consisting of 1 per cent proteose-peptone (Difco), and 0-1 per cent sodium acetate, dibasic potassium phosphate and yeast extract (Difco). During the last cold period all cells were collected gently by centrifugation, washed three ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2181271a0
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  • 9
    Electronic Resource
    Electronic Resource
    Antibody-dependent cellular cytotoxicity-mediated serotherapy against murine neuroblastoma (1982)
    Springer
    Cancer immunology immunotherapy 14 (1982), S. 117-123 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The in vitro and in vivo activity has been investigated of antisera prepared against a murine (C-1300) neuroblastoma line (MNB) capable of differentiation. An antibody-dependent cellular cytotoxicity (ADCC) reaction was employed using rat spleen cells (RSC). ADCC activity in vitro (using 51Cr-release) was shown, but a maximum of only 50% of the immunologically releasable 51Cr was achieved. Nevertheless, in vivo (syngeneic mouse-tumor flank assay) significant delays were obtained in tumor onset and lethality. Under ideal circumstances, i.e., coating of tumor cells prior to inoculation and high RSC effector cell ratios, a significant number of animals could be cured of substantial tumor burdens (106 cells). While close proximity of the site of injection of effector cells was required (ectopic injections of RSC were ineffective), the anti-MNB ADCC was shown to be quite active in vivo without external precoating of the cells with antisera. RCS obtained from BCG-treated rats were more numerous and slightly more effective. RSC obtained from γ-radiated animals retained normal activity. With appropriate antisera this approach could be useful under selected clinical circumstances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00200179
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  • 10
    Electronic Resource
    Electronic Resource
    Prognostic factors in the management of metastatic epidural spinal cord compression (1983)
    Springer
    Journal of neuro-oncology 1 (1983), S. 21-28 
    Details
    ISSN: 1573-7373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The results of 51 patients with metastatic spinal cord compression were analyzed. There were seven paralyzed patients, three received radiotherapy (RT) alone and four received laminectomy (L) + RT. No patient regained any motor function. Of six ambulatory patients, half received RT and half L + RT. All remained ambulatory after the treatment. Of 38 paraparetic patients, 20 underwent L + RT. Their complete, partial and nonresponse (CR, PR, NR respectively) rates were 25%, 60% and 15%, respectively. This result was clearly better than 18 other patients treated by RT alone of which only 22% regained ambulation (CR = 22%) while 67% were NR and 11% had a PR. In this series combined modality therapy appears better in paraparetic patients. Five patients with radiosensitive tumors all had CR/ PR whether treated by RT or L + RT. Patients with epithelial tumors treated by L + RT had a PR (CR + PR) of 71% while RT alone gave only 25%. On the basis of this analysis we conclude: (1) ambulatory patients respond satisfactorily to RT alone; (2) paraparetic patients with radiosensitive tumors do well with RT alone while such patients with epithelial tumors merit L + RT; but (3) paraplegic patients rarely benefit from either modality; (4) pain control appears a useful measure of minimally adequate radiation dose in individual patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00153637
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