ISSN:
0736-0266
Keywords:
Synovium
;
Articular cartilage
;
Osteoarthrosis
;
Hulth model
;
Life and Medical Sciences
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
The Hulth instability model was performed on 25 rabbit knee joints. Electron-microscopic, light-microscopic, and histomorphometric data demonstrated consistent chondrocyte alterations and cartilage destruction. The comparison between operated, sham, and control knees shows that surgical intervention without surgically induced instability is followed by changes in the synovial membrane and cartilage. The cartilage destruction is preceded by a synovial reaction, suggesting that the inflammatory response has an important role in the onset of cartilage damage in this model. The damage was more severe in the experimental knees, suggesting that mechanical instability is also a factor in cartilge destruction.
Additional Material:
17 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jor.1100060403
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