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  • 1
    Electronic Resource
    Electronic Resource
    Genetic changes in atypical hyperplasia and lymphoma with angioimmunoblastic lymphadenopathy and dysproteinaemia in the same patients (1994)
    Springer
    Virchows Archiv 425 (1994), S. 25-32 
    Details
    ISSN: 1432-2307
    Keywords: Angioimmunoblastic lymphadenopathy with dysproteinaemia ; Polymerase chain reaction ; T-cell receptor gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The transition between atypical hyperplasia and lymphoma with angioimmunoblastic lymphadenopathy and dysproteinaemia (AILD) was studied in serial lymp node biopsy specimens from five patients using DNA analysis with Southern blot analysis, polymerase chain reaction, chromosomal analysis, and immunophenotyping. The chromosomal analysis showed additional abnormalities as the disease progressed to those present initially, and immunological staining showed a corresponding increase in the numbers of CD4- and Ki67-positive cells. In the first biopsy from each patient a diagnosis of atypical hyperplasia with AILD was made and lymphoma excluding by the finding of only a few atypical lymphoid cells and the preservation of follicles with germinal centres. DNA analysis of lymph nodes at this stage showed either germ lines or oligoclonal rearrangements of the T-cell receptor (TCR) and immunoglobulin heavy chain genes. In the final biopsy, when a diagnosis of lymphoma with AILD was made, either a monoclonal rearrangement of the TCR was observed or one of the rearranged bands had increased in density. These results suggest selective proliferation of a clone of abnormal cells may account for the progression of atypical hyperplasia to lymphoma with AILD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193945
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    In vitro propagation, restriction fragment length polymorphism, and random amplified polymorphic DNA analyses of Angelica plants (1998)
    Springer
    Plant cell reports 18 (1998), S. 187-192 
    Details
    ISSN: 1432-203X
    Keywords: Key wordsAngelica ; Restriction fragment length polymorphism ; Random amplified polymorphic DNA ; Ligustilide ; In vitro propagation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Angelica acutiloba, a medicinal plant used as a natural medicine Touki, was clonally propagated through axillary buds in vitro. No substantial differences were found in the random amplified polymorphic DNA (RAPD) pattern between the original A. acutiloba and the plant propagated in vitro, suggesting no changes in the DNA sequences and structure during in vitro propagation. The genetic similarities of several Angelica plants were investigated by restriction fragment length polymorphism (RFLP) and RAPD analyses. The RFLP and RAPD patterns of A. sinensis Diels were substantially different from those of A. acutiloba. Using ten different restriction enzymes, no RFLP was observed in the varieties of A. acutiloba. By RAPD analysis, A. acutiloba varieties can be classified into two major subgroups, i.e., A. acutiloba Kitagawa and A. acutiloba Kitagawa var. sugiyamae Hikino. The varieties of A. acutiloba Kitagawa in Japan and Angelica spp. in northeast China exhibited a very close genetic relationship.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002990050554
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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