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  • 1
    Electronic Resource
    Electronic Resource
    Influence of lisuride on morphine withdrawal signs in the rat: A dopamine-mimetic effect (1982)
    Springer
    Psychopharmacology 78 (1982), S. 326-330 
    Details
    ISSN: 1432-2072
    Keywords: Morphine withdrawal ; Dopamine ; Lisuride ; N-n-propylnorapomorphine ; Haloperidol ; Sulpiride ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of lisuride on naloxone-induced withdrawal signs (wet shakes, escape attempts) was studied in morphine-dependent rats. Lisuride, injected IP at doses of 12.5 and 25 μg/kg, inhibited wet shakes while not significantly altering escape attempts induced by naloxone (4 mg/kg IP). At higher doses (50 and 100 μg/kg IP), lisuride's inhibitory effect on wet shakes persisted while escape attempts were actually potentiated with respect to control withdrawal rats. Increases in aggressive behavior were seen at all doses, and were dose-related. Haloperidol (0.3 mg/kg IP), administered 40 min before lisuride, did not modify the antagonistic effect on wet shakes, unlike sulpiride (40 mg/kg IP 30 min before lisuride), but at the same time blocked the increase in escape attempts and aggressiveness induced by lisuride. We suggest that lisuride modulates withdrawal signs by stimulation of dopamine receptors in the CNS. The effect of the dopamine mimetic N-n-propylnorapomorphine (NPA) on the same variables is reported as well as the influence of haloperidol on NPA, and a comparison between the effects of the two drugs is made.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433735
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The role of dopaminergic receptors in the behavioral effects induced by lisuride in male rats (1983)
    Springer
    Psychopharmacology 80 (1983), S. 38-42 
    Details
    ISSN: 1432-2072
    Keywords: Lisuride ; DA-receptors ; Penile erection ; Stretching and yawning ; Behavior ; Dopaminergic antagonists ; Methysergide ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Lisuride increased the incidence of stretching and yawning (SY) as well as of penile erection (PE) and elicited stereotyped behavior (SB), aggressive behavior and mounting in male rats, depending on the dose used. SY was prevented by two dopaminergic antagonists, haloperidol and sulpiride, but not by methysergide, a serotoninergic antagonist, while PE was antagonized by all three drugs. With regard to SB, aggressive behavior and mounting, all three were suppressed by haloperidol; sulpiride, while partially antagonizing aggressiveness, failed to affect SB and mounting; methysergide did not significantly influence any of the three. This suggests that lisuride principally affects the dopaminergic system. Although further detailed studies are required to elucidate which type of the complex population of DA-receptors is involved in each kind of behavior, we suggest that SY at least is due to the activation by lisuride of presynaptic DA-receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427492
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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