ISSN:
1432-2277
Keywords:
Lymphocytotoxic crossmatch
;
Positive crossmatch
;
Autoreactive antibodies
;
HLA antibodies
;
Transplantation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract There is no doubt that the interpretation of a positive lymphocytotoxic crossmatch test has changed over the past 10–15 years. It is now generally accepted that the original dogma put forward in the mid-1960s “that a renal transplant must not be performed in the presence of a positive lymphocytotoxic crossmatch” is no longer tenable, and many positive crossmatch transplants have already been successfully carried out. However, the precise conditions under which such a transplant can be performed are still not fully understood. Some factors which should be considered when deciding whether or not to transplant in the presence of a positive crossmatch are: (1) the specificity of the antibody, and this can be HLA class I, class II or non-HLA; (2) the time interval between the last positive crossmatch serum and transplantation; and (3) the immunoglobulin class of the antibody, either IgG or IgM.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02425963
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