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  • MRI  (3)
  • Scrapie  (2)
  • Supercritical fluid chromatography, SFC  (2)
  • ion selectivity  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Monocyte recruitment into the scrapie-affected brain (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 164-169 
    Details
    ISSN: 1432-0533
    Keywords: Key words Monocyte ; Scrapie ; Central nervous ; system ; Pathogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The recruitment of monocytes into the scrapie-affected brain was investigated in female mice reconstituted with male bone marrow, using a Y-chromosome-specific probe and F4/80 immunocytochemistry. Recruitment of monocytes could be demonstrated in six out of eight animals and the number of recruited cells correlated with the severity of vacuolation in most, but not all, animals. The proportion of microglia derived from recruited monocytes varied between individual animals, did not correlate with the increase in cellularity (glia) in affected areas of brain and did not affect the length of incubation period. Thus, it is unlikely that the recruitment of monocytes is a pivotal event in the development of early pathological changes in scrapie. The morphology of recruited cells in scrapie lesions, as revealed by F4/80 immunoreactivity, was indistinguishable from that of activated resident microglia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294316
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  • 2
    Electronic Resource
    Electronic Resource
    Monocyte recruitment into the scrapie-affected brain (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 164-169 
    Details
    ISSN: 1432-0533
    Keywords: Monocyte ; Scrapie ; Central nervous system ; Pathogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The recruitment of monocytes into the scrapie-affected brain was investigated in female mice reconstituted with male bone marrow, using a Y-chromosome-specific probe and F4/80 immunocytochemistry. Recruitment of monocytes could be demonstrated in six out of eight animals and the number of recruited cells correlated with the severity of vacuolation in most, but not all, animals. The proportion of microglia derived from recruited monocytes varied between individual animals, did not correlate with the increase in cellularity (glia) in affected areas of brain and did not affect the length of incubation period. Thus, it is unlikely that the recruitment of monocytes is a pivotal event in the development of early pathological changes in scrapie. The morphology of recruited cells in scrapie lesions, as revealed by F4/80 immunoreactivity, was indistinguishable from that of activated resident microglia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294316
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    T1, T2 and proton density measurements in the grading of cerebral gliomas (1993)
    Springer
    European radiology 3 (1993), S. 49-52 
    Details
    ISSN: 1432-1084
    Keywords: Brain tumor ; MRI ; T1 ; T2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The possibility that cerebral tumours may be graded by measuring T1 or T2 with magnetic resonance (MR) imaging was studied. A consecutive series of patients with subsequently verified gliomas was enrolled, and studied with MR. Patients who had prior surgical, chemotherapeutic or steroid treatment were excluded. Single slice multiple saturation recovery and multiple spin echo techniques were used to measure T1, T2 and proton density in the tumour. In 33 patients with cerebral gliomas there were 5 grade I, 12 grade II, 7 grade III and 9 grade IV. T1 and T2 values tended to be smaller in grade I gliomas than in grades II, III and IV gliomas. Relaxation parameters overlapped considerably in tumours with different grades. Proton density values did not show much change between different grades of gliomas. Relaxation parameters cannot be used to determine tumour grade reliably.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00173524
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  • 4
    Electronic Resource
    Electronic Resource
    Gradient recalled echo MR imaging of superior sagittal sinus occlusion (1989)
    Springer
    Neuroradiology 31 (1989), S. 134-136 
    Details
    ISSN: 1432-1920
    Keywords: Gradient recalled echo ; MRI ; Sinus occlusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary With T1-weighted gradient recalled echo (GRE) MR images and flow compensation, we studied the superior sagittal sinus in 3 normal volunteers and 3 patients with sinus occlusion. In these images, sites of patency of the superior sagittal sinus were identified due to the high signal intensity of the normal sinus. Tumor invading the sinus was nearly isointense with cerebral gray matter. T1-weighted GRE imaging proves to be an effective technique to evaluate sinus blood flow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00698840
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  • 5
    Electronic Resource
    Electronic Resource
    Technical factors in MR image quality (1986)
    Springer
    Neuroradiology 28 (1986), S. 74-77 
    Details
    ISSN: 1432-1920
    Keywords: Head ; MRI ; Image quality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the subjective rating of MR image quality as field strength, slice thickness, number of acquisitions and matrix size were varied. Matrix and number of acquisitions had the most significant effect on image quality. Therefore, in comparisons of image quality, technique must not be disregarded.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00341772
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  • 6
    Electronic Resource
    Electronic Resource
    The characterization of a monovalent cation-selective channel of mammalian cardiac muscle sarcoplasmic reticulum (1984)
    Springer
    The journal of membrane biology 80 (1984), S. 191-199 
    Details
    ISSN: 1432-1424
    Keywords: cardiac sarcoplasmic reticulum ; K+ channel ; ion selectivity ; decamethonium block
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Rabbit cardiac muscle sarcoplasmic reticulum (SR) was isolated and separated into ryanodine-sensitive and-insensitive fractions (L.R. Jones and S.E. Cala,J. Biol. Chem. 256:11809–11818, 1981). Vesicles of cardiac SR were incorporated into planar phospholipid bilayers by fusion and the channel activity of the membrane studied under voltage-clamp conditions (C. Miller,J. Membrane Biol. 40: 1–23, 1978). Both fractions contain a monovalent cation-selective three-state channel. In the presence of 75mm K2SO4, the fully open state (β) conductance of this channel is 157.2±30 pS and the sub-state (α) conductance is 100.7±21 pS. Both open states display the same selectivity sequence for monovalent cations, i.e. K+〉NH 4 + 〉Rb+〉Na+〉Li+ and may be blocked by the skeletal muscle relaxants decamethonium and hexamethonium. Block occurs when the compounds are added to either side of the membrane. The properties of the cardiac SR cation channel are compared with those of the previously reported monovalent cation-selective channels of mammalian and amphibian skeletal muscle SR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01868775
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  • 7
    Electronic Resource
    Electronic Resource
    Conduction and blocking properties of a predominantly anion-selective channel from human platelet surface membrane reconstituted into planar phospholipid bilayers (1989)
    Springer
    The journal of membrane biology 109 (1989), S. 113-122 
    Details
    ISSN: 1432-1424
    Keywords: platelet surface membrane ; lipid bilayer ; anion channel ; ion selectivity ; block
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary We have investigated the basic properties of a predominantly anion-selective channel derived from highly purified human platelet surface membrane. Single channels have been reconstituted into planar phospholipid bilayers by fusion of membrane vesicles and recorded under voltage-clamp conditions. The channel is found to have the following properties: (i) Channel activity occurs in bursts of openings separated by long closed periods. (ii) The current-voltage relationship is nonlinear. Channel current is seen to rectify, with less current flowing at positive than at negative voltages. Rectification may be due to asymmetric block by HEPES/Tris buffers. In 450mm KCl, 5mm HEPES/Tris, pH 7.2 the single channel conductance at −40 mV is ∼160 pS and at +40 mV is ∼90 pS. (iii) The conductanceconcentration relationship follows a simple saturation curve. Half maximal conductance is achieved at a concentration of ∼1000mm KCl, and the curve saturates at a conductance of ∼500 pS. (iv) Reversal potentials interpreted in terms of the Goldman-Hodgkin-Katz equation indicate a Cl∶K permeability ratio of 4∶1. (v) The channel accepts all of the halides as well as a number of other anions. The following sequence of relative anion permeabilities (in the presence of K+) is obtained: F−〈acetate−〈gluconate−〈Cl−〈Br−〈I−〈NO 3 − 〈SCN−. (vi) Cations as large as TEA+ are permeant. (vii) Current through the channel is blocked in the presence of DIDS, SITS and ATP, but not by Zn2+.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01870850
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Preparation of robust tapered restrictors for capillary supercritical fluid chromatography (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 289-291 
    Details
    ISSN: 0935-6304
    Keywords: Supercritical fluid chromatography, SFC ; Capillary columns ; Restrictor ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110314
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  • 9
    Electronic Resource
    Electronic Resource
    Supercritical fluid extraction / capillary supercritical fluid chromatography / Fourier transform infrared microspectrometry of polycyclic aromatic compounds in a coal tar pitch (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 766-775 
    Details
    ISSN: 0935-6304
    Keywords: Supercritical fluid extraction, SFE ; Supercritical fluid chromatography, SFC ; Fourier transform infrared microspectrometry, FTIR ; Narrow-bore capillary column ; Polycyclic aromatic compounds, PAC ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The combination of supercritical fluid extraction, high resolution capillary supercritical fluid chromatography, and Fourier transform infrared microspectrometry is described for the separation and identification of polycyclic aromatic hydrocarbons in a coal tar pitch. The variable solvating power of the supercritical fluid was utilized to selectively fractionate the sample. The fluid extract was decompressed through a frit restrictor into the sample cavity of a cooled microvalve injector, where the analytes were deposited and concentrated for subsequent chromatographic analysis. Several of the analytes separated in the chromatograph were collected on a potassium bromide disc at a solvent elimination inter-face for subsequent infrared analysis involving the use of an infra-red microscope accessory. The spectra obtained show the power of this detection technique for distinguishing between isomers.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240111105
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