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  • Maalox  (1)
  • satisfaction  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Influence of the antacid Maalox on the pharmacokinetics of capecitabine in cancer patients (1999)
    Springer
    Cancer chemotherapy and pharmacology 43 (1999), S. 309-315 
    Details
    ISSN: 1432-0843
    Keywords: Key words Capecitabine ; Pharmacokinetic interaction ; Maalox ; 5-Fluorouracil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: In the present study the possible influence of the antacid Maalox on the pharmacokinetics of capecitabine (Xeloda) and its metabolites was investigated in cancer patients. Methods: A total of 12 patients with solid, predominantly metastatic tumors of various origin received a single oral dose of 1250 mg/m2 of capecitabine (treatment A), a single oral dose of 1250 mg/m2 of capecitabine followed immediately by 20 ml of Maalox (treatment B), and a single oral dose of 1250 mg/m2 of capecitabine followed 2 h later by 20 ml of Maalox (treatment C) in an open, randomized, three-way cross over fashion. Serial blood and urine samples were collected for up to 24 h after each administration. Unchanged capecitabine and its metabolites were analyzed in plasma using liquid chromatography/mass spectrometry and in urine using nuclear magnetic resonance spectroscopy. Results: Administration of Maalox either concomitantly with capecitabine or delayed by 2 h did not influence the time to peak plasma concentrations (Cmax) or the elimination half-lives of capecitabine and its metabolites. Unexpectedly, moderate increases in the Cmax and AUC0–∞ values obtained for capecitabine and 5′-deoxy-5-fluorocytidine were observed when Maalox was given together with capecitabine. However, these increases, which ranged between 10% and 31%, were not statistically significant (P 〉 0.05) and are not of clinical significance. There was no indication of consistent changes in the plasma concentrations of the other metabolites 5′-deoxy-5′-fluorouridine (5′-DFUR), 5-fluorouracil, and α-fluoro-β-alanine. The Cmax and AUC0–∞ values recorded for these three metabolites increased and decreased in a stochastic manner. The magnitude of these changes was low (〈13%) and not statistically significant. The primary statistical analysis of the AUC0–∞obtained for 5′-DFUR provided a P value of 0.4524 and clearly indicated no significant difference between the treatments. The addition of Maalox had no influence on the overall urinary recovery or the proportion of the dose recovered as capecitabine or its metabolites from urine. Conclusion: At the dose used in this study, the effect of concomitantly delivered Maalox on the extent and rate of gastrointestinal absorption of capecitabine is not clinically significant. Therefore, there is no need to adjust the dose or timing of capecitabine administration in patients treated with Maalox.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050900
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Sexual interest, activity, and satisfaction among male nursing home residents (1991)
    Springer
    Archives of sexual behavior 20 (1991), S. 199-204 
    Details
    ISSN: 1573-2800
    Keywords: sex ; nursing home ; satisfaction ; distress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract Structured interviews were conducted with all male residents (n = 116) of a Veterans Affairs Nursing Home to gather information on sexual interest, preference, activity levels, satisfaction, and distress. We excluded males with severe cognitive impairment, leaving a sample of 61. Of these, 30 had partners. Sexual interest was significantly higher among those with partners (p = 0.014), although those without partners reported that their interest would have been higher if they had a sexual partner. Sexual preference was strongly in favor of vaginal intercourse, regardless of the presence or absence of a partner. Among those with partners, coitus was reported to occur at least monthly by 17%, and other forms of sexual activity (e.g., hugging, kissing) were practiced at least monthly by 73%. Sexual satisfaction was high, and distress with relative sexual inactivity was remarkably low. We found age, functional status, and intercourse frequency to correlate positively with sexual satisfaction, whereas marital status, cognitive function, libido, and frequency of kissing were positive correlates of sexual distress. Institutionalized elderly males remain sexually interested, especially in coitus, and may benefit from counseling and home visits when a partner is available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01541944
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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