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  • 1
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    Justifying Moral Initiative by Business, with Rejoinders to Bill Shaw and Richard Nunan (1990)
    Dordrecht : Periodicals Archive Online (PAO)
    Journal of Business Ethics. 9:2 (1990:Feb.) 93 
    Details
    ISSN: 0167-4544
    Topics: Philosophy , Economics
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:m089-1990-009-02-000002
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  • 2
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    A Critique of Milton Friedman's Essay 'The Social Responsibility of Business Is to Increase Its Profits' (1986)
    Dordrecht : Periodicals Archive Online (PAO)
    Journal of Business Ethics. 5:4 (1986:Aug.) 265 
    Details
    ISSN: 0167-4544
    Topics: Philosophy , Economics
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:m089-1986-005-04-000001
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  • 3
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    R. Edward Freeman and Daniel R. Gilbert, Jr., "Corporate Strategy and the Search for Ethics" (Book Review) (1992)
    Dordrecht : Periodicals Archive Online (PAO)
    Journal of Business Ethics. 11:7 (1992:July) 514 
    Details
    ISSN: 0167-4544
    Topics: Philosophy , Economics
    Notes: Book Review
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:m089-1992-011-07-000010
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of the antacid Maalox on the pharmacokinetics of capecitabine in cancer patients (1999)
    Springer
    Cancer chemotherapy and pharmacology 43 (1999), S. 309-315 
    Details
    ISSN: 1432-0843
    Keywords: Key words Capecitabine ; Pharmacokinetic interaction ; Maalox ; 5-Fluorouracil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: In the present study the possible influence of the antacid Maalox on the pharmacokinetics of capecitabine (Xeloda) and its metabolites was investigated in cancer patients. Methods: A total of 12 patients with solid, predominantly metastatic tumors of various origin received a single oral dose of 1250 mg/m2 of capecitabine (treatment A), a single oral dose of 1250 mg/m2 of capecitabine followed immediately by 20 ml of Maalox (treatment B), and a single oral dose of 1250 mg/m2 of capecitabine followed 2 h later by 20 ml of Maalox (treatment C) in an open, randomized, three-way cross over fashion. Serial blood and urine samples were collected for up to 24 h after each administration. Unchanged capecitabine and its metabolites were analyzed in plasma using liquid chromatography/mass spectrometry and in urine using nuclear magnetic resonance spectroscopy. Results: Administration of Maalox either concomitantly with capecitabine or delayed by 2 h did not influence the time to peak plasma concentrations (Cmax) or the elimination half-lives of capecitabine and its metabolites. Unexpectedly, moderate increases in the Cmax and AUC0–∞ values obtained for capecitabine and 5′-deoxy-5-fluorocytidine were observed when Maalox was given together with capecitabine. However, these increases, which ranged between 10% and 31%, were not statistically significant (P 〉 0.05) and are not of clinical significance. There was no indication of consistent changes in the plasma concentrations of the other metabolites 5′-deoxy-5′-fluorouridine (5′-DFUR), 5-fluorouracil, and α-fluoro-β-alanine. The Cmax and AUC0–∞ values recorded for these three metabolites increased and decreased in a stochastic manner. The magnitude of these changes was low (〈13%) and not statistically significant. The primary statistical analysis of the AUC0–∞obtained for 5′-DFUR provided a P value of 0.4524 and clearly indicated no significant difference between the treatments. The addition of Maalox had no influence on the overall urinary recovery or the proportion of the dose recovered as capecitabine or its metabolites from urine. Conclusion: At the dose used in this study, the effect of concomitantly delivered Maalox on the extent and rate of gastrointestinal absorption of capecitabine is not clinically significant. Therefore, there is no need to adjust the dose or timing of capecitabine administration in patients treated with Maalox.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050900
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  • 5
    Electronic Resource
    Electronic Resource
    Book review (1992)
    Springer
    Journal of business ethics 11 (1992), S. 514-514 
    Details
    ISSN: 1573-0697
    Source: Springer Online Journal Archives 1860-2000
    Topics: Philosophy , Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00881443
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  • 6
    Electronic Resource
    Electronic Resource
    Justifying moral initiative by business, with rejoinders to Bill Shaw and Richard Nunan (1990)
    Springer
    Journal of business ethics 9 (1990), S. 93-103 
    Details
    ISSN: 1573-0697
    Source: Springer Online Journal Archives 1860-2000
    Topics: Philosophy , Economics
    Notes: Abstract In this paper I respond to separate criticisms by Bill Shaw (JBE, July 1988) and Richard Nunan (JBE, December 1988) of my paper “A Critique of Milton Friedman's Essay ‘The Social Responsibility of Business Is to Increase Its Profits’” (JBE, August 1986). Professors Shaw and Nunan identify several points where my argument could benefit from clarification and improvement. They also make valuable contributions to the discussion of the broad issue area of whether and to what extent business should exercise moral initiative. My objectives are (1) to show, with the aid of examples (inspired by Shaw) and the addition of one point of correction (inspired by Nunan), that my disapproving critique of Friedman's famous argument remains sound, (2) to show that Professor Shaw's argument contains serious problems, and (3) to build on the base laid by my critics by developing important reasons why business should exercise moral initiative.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00382658
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  • 7
    Electronic Resource
    Electronic Resource
    A critique of Milton Friedman's essay ‘the social responsibility of business is to increase its profits’ (1986)
    Springer
    Journal of business ethics 5 (1986), S. 265-269 
    Details
    ISSN: 1573-0697
    Source: Springer Online Journal Archives 1860-2000
    Topics: Philosophy , Economics
    Notes: Abstract The main arguments of Milton Friedman's famous and influential essay are unsuccessful: He fails to prove that the exercise of social responsibility in business is by nature an unfair and socialist practice. Much of Friedman's case is based on a questionable paradigm; a key premise is false; and logical cogency is sometimes missing. The author proposes a different paradigm for socially responsible action in business and argues that a commitment to social responsibility can be an integral element in strategic and operational business management without producing any of the objectionable results claimed by Friedman.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00383091
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  • 8
    Electronic Resource
    Electronic Resource
    Sexuality and aging in male veterans: A cross-sectional study of interest, ability, and activity (1991)
    Springer
    Archives of sexual behavior 20 (1991), S. 17-25 
    Details
    ISSN: 1573-2800
    Keywords: aging ; libido ; erections ; intercourse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract To gather data on sexuality, specifically in male veterans, and to test the hypothesis that aged males remain interested in sexual intercourse yet suffer from erectile failure, veterans age 30 to 99 were surveyed. The mailed survey had 88 questions and was pretested on young potent males and aged impotent males. From 1031 randomly selected subjects, there were 806 replies: 427 completed surveys, 247 refusals, and 132 who were too ill to participate (225 failed to reply). Among responders, sexual interest declined from a mean of 4.4/5 (4 = very interested, 5 = extremely interested) in men age 30–39 years to 2.0/5 (2 = slightly interested) in men age 90–99 (p 〈 0.0001). Vaginal intercourse was consistently the preferred sexual activity; however, intercourse frequency was diminished from a mean of once per week in 30- to 39-year-olds to once per year in 90- to 99-year-olds (p 〈 0.0001). Frequency, rigidity, and duration of erections were less in aged compared to younger cohorts (p 〈 0.0001). With these facts in mind, further research to bridge the libido-potency gap is warranted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01543004
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  • 9
    Electronic Resource
    Electronic Resource
    Sexual interest, activity, and satisfaction among male nursing home residents (1991)
    Springer
    Archives of sexual behavior 20 (1991), S. 199-204 
    Details
    ISSN: 1573-2800
    Keywords: sex ; nursing home ; satisfaction ; distress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract Structured interviews were conducted with all male residents (n = 116) of a Veterans Affairs Nursing Home to gather information on sexual interest, preference, activity levels, satisfaction, and distress. We excluded males with severe cognitive impairment, leaving a sample of 61. Of these, 30 had partners. Sexual interest was significantly higher among those with partners (p = 0.014), although those without partners reported that their interest would have been higher if they had a sexual partner. Sexual preference was strongly in favor of vaginal intercourse, regardless of the presence or absence of a partner. Among those with partners, coitus was reported to occur at least monthly by 17%, and other forms of sexual activity (e.g., hugging, kissing) were practiced at least monthly by 73%. Sexual satisfaction was high, and distress with relative sexual inactivity was remarkably low. We found age, functional status, and intercourse frequency to correlate positively with sexual satisfaction, whereas marital status, cognitive function, libido, and frequency of kissing were positive correlates of sexual distress. Institutionalized elderly males remain sexually interested, especially in coitus, and may benefit from counseling and home visits when a partner is available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01541944
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  • 10
    Electronic Resource
    Electronic Resource
    The importance of intimacy to men living in a nursing home (1994)
    Springer
    Archives of sexual behavior 23 (1994), S. 231-236 
    Details
    ISSN: 1573-2800
    Keywords: intimacy ; aged ; nursing home
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract Intimacy and its contribution to life satisfaction have not been explored among institutionalized elders. We studied residents of a Veterans Affairs nursing home and assessed cognitive and physical function, life satisfaction, and importance of intimacy. The Folstein Mini-Mental State, Barthel Index, Life Satisfaction Index-Z, and a series of vignettes were used to assess each domain. Vignettes depicted various scenarios (e.g., recent admission to a nursing home, notification of diagnosis of a terminal disease), and asked the subject to rate the importance of intimate social, intellectual, emotional, or physical interactions. Social intimacy was rated as most important, followed by nonsexual physical, intellectual, emotional, and finally, sexual-physical intimacy (social vs. sexual-physical, p =0.0013). In addition, social (rs =.299, p =0.023), nonsexual physical (rs =.312, p =0.019), and intellectual (rs =.382, p =0.005) intimacy were associated with life satisfaction. Nursing home care providers can enhance resident quality of life through social, intellectual, and nonsexual physical interactions even when the underlying medical, physical, or cognitive deficit cannot be ameliorated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01542101
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