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  • Maximal exercise  (2)
  • propranolol  (2)
  • Propranolol  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Beta-blockade and lipolysis during endurance exercise (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 101-105 
    Details
    ISSN: 1432-1041
    Keywords: Lipolysis ; Propranolol ; beta-blockade ; endurance exercise ; glycerol ; NEFA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Inhibition of adipose tissue lipolysis may be involved in the impairment of endurance capacity after administration of a β-adrenoceptor blocker. During endurance exercise, no significant decrease in plasma glycerol and free fatty acid (NEFA) concentrations after β-adrenoceptor blockade is found. However, the levels during recovery from exhaustion are lower after β-adrenoceptor blockade. This study was designed to investigate whether the lower levels after exercise are due to β-adrenoceptor blockade or to the shorter time to exhaustion after administration of a β-adrenoceptor blocker. In a single-blind study, 11 well-trained male subjects (age 23 (0.9) y) performed a cycle ergometer test at 70% Wmax until exhaustion 2 h after intake of 80 mg propranolol. One week later, the test was repeated after intake of placebo and was stopped at the time of exhaustion in the previous test. Average exercise time was 24 min. During exercise plasma glucose was lower, whereas plasma lactate and the respiratory exchange ratio were significantly higher when the subjects were on propranolol. Glycerol and NEFA concentrations during exercise were not significantly different between the two conditions. Despite an identical exercise time, glycerol and NEFA concentrations during recovery were significantly lower after propranol treatment. In conclusion, lipolysis is inhibited during exercise after propranolol, probably causing a shift from fat to carbohydrate combustion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315488
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of acute and long-term beta-adrenoceptor blockade with propranolol on haemodynamics, plasma catecholamines and renin in essential hypertension (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 377-382 
    Details
    ISSN: 1432-1041
    Keywords: propranolol ; essential hypertension ; acute and chronic treatment ; haemodynamic effects ; plasma renin ; plasma catecholamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of an acute intravenous and repeated oral doses of propranolol on haemodynamics, plasma and urinary catecholamines and plasma renin activity was studied in patients with essential hypertension. Intravenous injection of propranolol 5 mg produced a fall in cardiac output but had no consistent effect on blood pressure. Treatment with oral propranolol for 24 weeks lowered cardiac output and blood pressure; total peripheral resistance did not differ from the pretreatment values. Neither acute intravenous nor chronic oral administration of the beta-blocker affected the resting plasma levels of noradrenaline and adrenaline. Long-term treatment with propranolol reduced urinary excretion of vanilmandelic acid without affecting urinary catecholamine excretion. Acute intravenous injection of propranolol decreased plasma renin activity less than did chronic oral treatment with the drug. The observed time course of plasma renin activity was compatible with the view that suppression of this enzyme contributed to the antihypertensive effect of propranolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00605985
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of physical exercise on the pharmacokinetics of propranolol (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 375-377 
    Details
    ISSN: 1432-1041
    Keywords: propranolol ; pharmacokinetics ; exercise ; indocyanine green clearance ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of propranolol after oral and intravenous administration was studied at rest and on an exercise day in 8 healthy subjects. On the exercise day the subjects performed physical exercise for 7 h, consisting of bicycle ergometer exercise at 50% of maximal work capacity and outdoor walking. Propranolol (80 mg p.o., or 0.2 mg/kg body weight i.v.) was administered 30 min before the start of the exercise. After oral administration the terminal phase halflife, (t1/2β) and area under the curve (AUC) were both significantly reduced on the exercise day compared to the rest day. The bioavailability of propranolol was reduced by prolonged physical exercise and plasma levels of propranolol were about 30% lower at the end of the exercise day than at the end of the rest day. After intravenous administration, t1/2β was also reduced on the exercise day as compared to the rest day. AUC, clearance and volume of distribution did not differ on the two days. On the other hand, indocyanine green (ICG) clearance was significantly reduced during the bicycle ergometry periods on the exercise day. The combination of reduced ICG clearance, suggesting a reduction in hepatic blood flow, and a decreased t1/2β and unchanged clearance of propranolol on the exercise day was unexpected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00981142
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of verapamil on cardiovascular and metabolic responses to exercise (1986)
    Springer
    European journal of applied physiology 55 (1986), S. 499-502 
    Details
    ISSN: 1439-6327
    Keywords: Verapamil ; Maximal exercise ; Side-effect ; Metabolism ; Heart rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a double-blind cross-over study, the effects of verapamil on the cardiovascular and metabolic changes during a progressive maximal exercise test were studied in 12 healthy volunteers. Each subject was treated with placebo and verapamil in 3 different dosages: 3×40, 3×80 and 3×120 mg · d−1 in random order. Drugs were administered for 2 days; on the 3rd day, 2 h after the last dose, a progressive exercise test until exhaustion was performed on a bicycle ergometer. No significant differences in maximal exercise capacity were found between the 4 groups of medication. $$\dot V_{{\text{O}}_{\text{2}} }$$ , $$\dot V_{CO_2 }$$ , and $$\dot V_E $$ were also unaffected by verapamil administration. Heart rate during exercise was reduced dose-dependently (p〈0.001). With the highest dose of verapamil, maximal heart rate was reduced by 13±1 beats · min−1. No effect could be shown on parameters of carbohydrate and fat metabolism. Perceived exertion, estimated by the Borg scale, did not differ between placebo and the 3 medication groups. The study shows that despite a distinct reduction of heart rate, maximal exercise capacity remains unaffected after verapamil use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421644
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  • 5
    Electronic Resource
    Electronic Resource
    Maximal heart rates and plasma lactate concentrations observed in middle-aged men and women during a maximal cycle ergometer test (1993)
    Springer
    European journal of applied physiology 66 (1993), S. 281-284 
    Details
    ISSN: 1439-6327
    Keywords: Lactate ; Heart rate ; Exercise tests ; Sex difference ; Maximal exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this study was to investigate criteria for maximal effort in middle-aged men and women undertaking a maximal exercise test until they were exhausted if no measurements of oxygen uptake are made. A large group of 2164 men and 975 women, all active in sports and aged between 40 and 65 years, volunteered for a medical examination including a progressive exercise test to exhaustion on a cycle ergometer. In the 3rd min of recovery a venous blood sample was taken to determine the plasma lactate concentration ([la−]p, 3min). Lactate concentration and maximal heart rate (f c, max) were lower in the women than in the men (P〈0.001). Multiple regression analyses were performed to assess the contribution of sex to [la−]p, 3 min, independent of age and f c max, It was found that [la−]p,3 min was about 2.5 mmol·l−1 lower in women than in men of the same age and f c, max. In our population 88% of the men and 85% of the women met a combination of the following f c, max and [la−]p, 3min criteria: f c, max equal to or greater than 220 minus age beats·min−1 and/or [la−]p, 3min equal to or greater than 8 mmol·l−1 in the men and f c, max equal to or greater than 220 minus age beats·min−1 and/or [la−]p, 3min equal to or greater than 5.5 mmol·1−1 in the women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235107
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