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  • Melatonin  (1)
  • Surgery of the colon  (1)
  • intraoperative Dickdarmspülung  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Prevention of cytokine-induced hypotension in cancer patients by the pineal hormone melatonin (1996)
    Springer
    Supportive care in cancer 4 (1996), S. 313-316 
    Details
    ISSN: 1433-7339
    Keywords: Hypotension ; Immunotherapy ; Interleukin-2 ; Melatonin ; Nitric oxide ; Tumour necrosis factor α
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hypotension is a frequent side-effect of cancer biotherapies with cytokines. Cytokine-induced hypotension would mainly depend on the stimulation of nitric oxide (NO) production, which represents the most effective endogenous vasodilator. Moreover, it has been proven that both biological activity and toxicity of cytokines are influenced by the psychoneuroendocrine system, in particular by the pineal hormone melatonin. To investigate the possible modulatory effect of melatonin on cytokine cardiovascular toxicity, we evaluated the influence of a concomitant melatonin administration on interleukin-2(IL-2)- and tumour-necrosis-factor-α(TNF)-induced hypotension in advanced cancer patients. The study included 116 patients with advanced solid tumour, for whom no effective standard anticancer therapy was available, who underwent cancer biotherapy with IL-2 (3 × 106 IU/day s.c. every day, 6 days/week for 4 weeks) or with TNF (0.75 mg/day i.v. for 5 days) as compassionate treatment for their disease. Patients were randomized to be treated with or without a concomitant melatonin administration (40 mg/day orally in the evening, starting 7 days prior to cytokine injection). The occurrence of hypotension was significantly less frequent in patients concomitantly treated by melatonin than in those who received the cytokine alone, during either IL-2 or TNF immunotherapy (IL-2: 11/45 versus 2/46,P〈0.05; TNF: 10/23 versus 1/12,P〈0.01). This study shows that melatonin may prevent hypotension occurring during cancer immunotherapy with IL-2 or TNF. Since the pineal hormone has appeared to inhibit the activity of NO synthase from the endothelial cells, we suggest that melatonin may prevent cytokine-induced hypotension by inhibiting NO production, which plays an essential role in inducing hypotension during IL-2 and TNF biotherapies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01358887
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    221. über die Anwendung einer neuen intraoperativen Darmspülmethode bei notfallmäßigen Colonresektionen (1982)
    Springer
    Langenbeck's archives of surgery 358 (1982), S. 519-519 
    Details
    ISSN: 1435-2451
    Keywords: Emergency large bowel resections ; Peroperative large bowel irrigation ; Surgery of the colon ; Notfallmäßige Colonresektionen ; intraoperative Dickdarmspülung ; Dickdarmchirurgie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde von uns bei 15 Fällen von notfallmäßigen linksseitigen Colonresektionen die neue von Dudley (1980) entwickelte intraoperative Dickdarmspülungsmethode angewandt (d. h. eine der Resektionsstelle proximale Colotomie, dortige Einführung eines ableitenden Irrigationsschlauches, distale Ileotomie und Einführung ins Coecum durch die Valvula Bauhini eines Foley Katheters, mittels desselben Irrigation des Darmes. Die Ergebnisse waren sehr positiv: keine Anastomosendehiscenz, saubere Colonstümpfe, mäßiger Zeitverlust.
    Notes: Summary We used Dudley's method of peroperative irrigation (1980) in 15 cases of resection of the left colon. Irrigation is achieved by means of a Foley catheter inserted through a distal ileotomy as far as the cecum, and drainage is provided by a tube placed just proximal to the portion of bowel to be resected. Results were very good; we had no leakage of anastomoses, clean bowel sections, and a minimal waste of time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271967
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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