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  • 1
    Electronic Resource
    Electronic Resource
    Optical feedback induced mesoscopic effects in semiconductor lasers
    Amsterdam : Elsevier
    Physics Letters A 175 (1993), S. 5-10 
    Details
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9601(93)90844-P
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Adjuvant therapy with the pineal hormone melatonin in patients with lymph node relapse due to malignant melanoma (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of pineal research 21 (1996), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Several experimental studies have shown that melatonin has an oncostatic action, either by stimulating host antitumor immune defenses or by directly inhibiting the growth of some cancer histotypes, including melanoma. Our previous clinical studies demonstrated that melatonin may induce stabilization of the disease in untreatable metastatic solid tumor patients, and these results have been confirmed by others, at least in patients with metastatic melanoma. On the contrary, at present there are no data related to the possible efficacy of melatonin as an adjuvant endocrine therapy. This study was performed to investigate the impact of melatonin therapy on the disease-free survival (DFS) in melanoma patients surgically treated for regional node recurrence. The study included 30 node-relapsed melanoma patients, who were randomized to receive no treatment or adjuvant therapy of melatonin (20 mg/day orally in the evening) every day until disease progression. After a median follow-up of 31 months, the percent of DFS was significantly higher in melatonin-treated individuals than in controls. The DFS curve was also significantly longer in melatonin group than in controls. No melatonin-related toxicity was observed. This preliminary study suggests that an adjuvant endocrine therapy with melatonin may be effective in preventing disease progression in node-relapsed melanoma patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-079X.1996.tb00292.x
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  • 3
    Electronic Resource
    Electronic Resource
    Prevention of cytokine-induced hypotension in cancer patients by the pineal hormone melatonin (1996)
    Springer
    Supportive care in cancer 4 (1996), S. 313-316 
    Details
    ISSN: 1433-7339
    Keywords: Hypotension ; Immunotherapy ; Interleukin-2 ; Melatonin ; Nitric oxide ; Tumour necrosis factor α
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hypotension is a frequent side-effect of cancer biotherapies with cytokines. Cytokine-induced hypotension would mainly depend on the stimulation of nitric oxide (NO) production, which represents the most effective endogenous vasodilator. Moreover, it has been proven that both biological activity and toxicity of cytokines are influenced by the psychoneuroendocrine system, in particular by the pineal hormone melatonin. To investigate the possible modulatory effect of melatonin on cytokine cardiovascular toxicity, we evaluated the influence of a concomitant melatonin administration on interleukin-2(IL-2)- and tumour-necrosis-factor-α(TNF)-induced hypotension in advanced cancer patients. The study included 116 patients with advanced solid tumour, for whom no effective standard anticancer therapy was available, who underwent cancer biotherapy with IL-2 (3 × 106 IU/day s.c. every day, 6 days/week for 4 weeks) or with TNF (0.75 mg/day i.v. for 5 days) as compassionate treatment for their disease. Patients were randomized to be treated with or without a concomitant melatonin administration (40 mg/day orally in the evening, starting 7 days prior to cytokine injection). The occurrence of hypotension was significantly less frequent in patients concomitantly treated by melatonin than in those who received the cytokine alone, during either IL-2 or TNF immunotherapy (IL-2: 11/45 versus 2/46,P〈0.05; TNF: 10/23 versus 1/12,P〈0.01). This study shows that melatonin may prevent hypotension occurring during cancer immunotherapy with IL-2 or TNF. Since the pineal hormone has appeared to inhibit the activity of NO synthase from the endothelial cells, we suggest that melatonin may prevent cytokine-induced hypotension by inhibiting NO production, which plays an essential role in inducing hypotension during IL-2 and TNF biotherapies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01358887
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  • 4
    Electronic Resource
    Electronic Resource
    221. über die Anwendung einer neuen intraoperativen Darmspülmethode bei notfallmäßigen Colonresektionen (1982)
    Springer
    Langenbeck's archives of surgery 358 (1982), S. 519-519 
    Details
    ISSN: 1435-2451
    Keywords: Emergency large bowel resections ; Peroperative large bowel irrigation ; Surgery of the colon ; Notfallmäßige Colonresektionen ; intraoperative Dickdarmspülung ; Dickdarmchirurgie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde von uns bei 15 Fällen von notfallmäßigen linksseitigen Colonresektionen die neue von Dudley (1980) entwickelte intraoperative Dickdarmspülungsmethode angewandt (d. h. eine der Resektionsstelle proximale Colotomie, dortige Einführung eines ableitenden Irrigationsschlauches, distale Ileotomie und Einführung ins Coecum durch die Valvula Bauhini eines Foley Katheters, mittels desselben Irrigation des Darmes. Die Ergebnisse waren sehr positiv: keine Anastomosendehiscenz, saubere Colonstümpfe, mäßiger Zeitverlust.
    Notes: Summary We used Dudley's method of peroperative irrigation (1980) in 15 cases of resection of the left colon. Irrigation is achieved by means of a Foley catheter inserted through a distal ileotomy as far as the cecum, and drainage is provided by a tube placed just proximal to the portion of bowel to be resected. Results were very good; we had no leakage of anastomoses, clean bowel sections, and a minimal waste of time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271967
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Asymmetrical response of semiconductor lasers in optical systems (1994)
    Springer
    Theoretical and mathematical physics 99 (1994), S. 648-652 
    Details
    ISSN: 1573-9333
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract The symmetry of the optical outputs of a semiconductor laser diode having front and rear facets with equal reflectivity is destroyed by the injection of a reflected signal, even of weak intensity, from one side: this asymmetry must be taken into account when designing laser packages and integrated circuits. A systematic experimental investigation is presented. Moreover, the behaviour of the system, i.e., the appearance of certain asymmetrical features together with the survival of the symmetry of other features, can be accounted for on the basis of a microscopic model, providing a link between the optical outputs from the two facets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01017046
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    Paper (German National Licenses)
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