ISSN:
0170-2041
Keywords:
Narbosines
;
Metabolites, secondary
;
Streptomyces
;
Rhodinosides
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
In the culture broth of two new Strepomyces strains several novel 2,3,6-trideoxy-L-threo-hexose (rhodinose) metabolites, narbosines A to E (2-6, 8, 9), were detected besides α-N-acetylanhydro-L-ornithine (11) by using the chemical screening method. Their structures were deduced from spectroscopical data as well as from chemical transformations. Narbosine A (2/3) was shown to be a 1:1 anomeric mixture of α-L-rhodinopyranosyl-(1→4) -α/β-L-rhodinopyranose, the others are partially oxidatively and reductively transformed derivatives of 2/3. A destinct antiviral activity was observed for the described metabolites.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.1991199101104
Permalink