ISSN:
1432-0533
Keywords:
Nervous System
;
Domestic Goat
;
Transmissible Granulomatous Encephalomyelitis
;
Light and Electronmicroscopy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary During the past five years a disease involving mainly the CNS was observed among adult and older animals in a flock of goats. Debilitating factors appear to favour the onset of the clinical manifestation. These are usually ushered in by a short febrile episode. The course, as a rule, is chronic with frequent recurrences. Clinical signs include ataxia, coarse tremor, nystagmus, torticollis, trismus, excess salivation, weakness of the hindquarters or complete paralysis. The serum globulins are abnormally elevated, particularly the gamma fraction. High levels of total protein, glucose and transaminases are common in the CSF. Neuropathologically, two types of changes are found, often blending together in a smooth fashion, namely, a chiefly granulomatous lesion in periventricular, paraventricular regions and meningeal spaces respectively and a predominantly demyelinating process reaching out from the paraventricular areas into the adjacent nervous parenchyma. A neurologic illness of the domestic goat—clinically and pathologically very similar to the spontaneous gMEM—was repeatedly obtained by injection of a cell-free filtrate into the cisterna magna prepared from a saline suspension of organ-material of a gMEM-animal. Final etiologic elucidation of this affection in goats, however, is yet to be accomplished.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00689005
Permalink
