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  • Mitochondrial enzymes  (1)
  • Rat  (1)
  • arterial blood pressure  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Pharmacokinetic and pharmacodynamic studies of oral clonidine in normotensive subjects (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 1-5 
    Details
    ISSN: 1432-1041
    Schlagwort(e): clonidine ; noradrenaline ; pharmacokinetics ; arterial blood pressure ; plasma concentration
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of clonidine and its relation to blood pressure response and side effects were studied after single oral doses of 75 µg, 150 µg and 250 µg in normotensive subjects. Following oral administration, the drug was absorbed rapidly after an initial lag time of 19–22 min and peak levels were reached between 2.4 and 2.9 h. Sampling over 48 h was necessary for accurate estimation of pharmacokinetic parameters. Post-peak plasma concentration declined in a monoexponential manner and the half-life of the elimination phase ranged from 9.0 to 15.1 h. Maximum plasma concentration (Cmax) and area under curve (AUC) increased proportionally with increasing doses. Clonidine produced significant reductions in the pulse rate and a dose dependent decrease in blood pressure. Clonidine (150 µg) also produced significant reductions in plasma catecholamine levels.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01061368
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  • 2
    Digitale Medien
    Digitale Medien
    Excitatory amino acid receptors in the caudal ventrolateral medulla mediate a vagal cardiopulmonary reflex in the rat (1989)
    Springer
    Experimental brain research 78 (1989), S. 185-192 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Cardiopulmonary vagal reflex ; Bezold-Jarisch reflex ; Excitatory amino acid ; Caudal ventrolateral medulla ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The importance of the caudal ventrolateral medulla (CVLM) in mediating vagal cardiopulmonary (Bezold-Jarisch reflex) reflex activity was studied in urethane-anaesthetized rats. Unilateral electrolytic lesion of the CVLM markedly attenuated Bezold-Jarisch reflex responses (hypotension and bradycardia) elicited by intravenous injections of 5-HT. Bilateral lesion of the CVLM virtually abolished the reflex responses. Microinjection of the excitatory amino acid (EAA) receptor antagonist kynurenate (KYN), but not the inactive analogue xanthurenate, into the CVLM markedly attenuated the reflex responses to 5-HT. The N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801 also markedly attenuated reflex activity. Furthermore, lesions, KYN and MK-801 all tended to elevate resting blood pressure and to reduce resting heart rate. These findings support the hypothesis that the CVLM is an important medullary locus mediating cardiovascular reflex integration and that an EAA synapse in the CVLM is important in the cardiopulmonary reflex arc.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00230698
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  • 3
    Digitale Medien
    Digitale Medien
    Mitochondrial abnormalities in human phaeochromocytoma (1976)
    Springer
    Cell & tissue research 172 (1976), S. 281-288 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Phaeochromocytoma ; Adrenal medulla ; Mitochondrial ultrastructure ; Mitochondrial enzymes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Mitochondrial abnormalities are reported in four cases of phaeochromocytoma. These abnormalities include swelling and scant cristae, intramitochondrial dense bodies, septate-like junctions, intercristal fusion plus spheroidal bodies, and intramitochondrial rodlets. These structural mitochondrial changes are associated with reduction in activity of the mitochondrial enzymes, monoamine oxidase and succinic dehydrogenase.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00226032
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