ISSN:
1432-1440
Keywords:
Molsidomine
;
SIN 1
;
Guanylate cyclase
;
Cyclic GMP
;
Platelet aggregation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary To find out whether 3-morpholino-sydnonimine (SIN 1), the active metabolite of molsidomine, exerts its antiaggregatory effects not only in vitro but also in vivo, we tested ex vivo aggregation before and after intravenous application of molsidomine in healthy volunteers. We also measured plasma levels of guanosine 3′∶5′-cyclic monophosphate (cyclic GMP) as SIN 1, the bioactive metabolite of molsidomine, becomes effective via activation of soluble guanylate cyclase. In eight out of ten subjects molsidomine had an inhibitory effect on platelet aggregation and a higher threshold concentration of platelet-activating factor was required after molsidomine application to induce irreversible aggregation. Despite the effect on platelets, plasma cyclic GMP levels did not increase. These results suggest that the nitric oxide-containing SIN 1 inhibits platelet aggregation not only in vitro but also in vivo and that this property can be a beneficial effect in antianginal therapy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01662718
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