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  • 1
    Electronic Resource
    Electronic Resource
    Relapsing inflammatory demyelinating polyneuropathy in a diabetic patient (1986)
    Springer
    Acta neuropathologica 71 (1986), S. 94-99 
    Details
    ISSN: 1432-0533
    Keywords: Diabetes mellitus ; Guillain-Barré syndrome ; Myelin ; Polyneuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Inflammatory demyelinating polyradiculoneuropathies exhibit well-known ultrastructural lesions of the peripheral nerve, both in acute cases, i.e., Guillain-Barré syndrome, and in relapsing, subacute and chronic cases. We present a case of relapsing inflammatory demyelinating polyradiculoneuropathy in a diabetic patient with a biopsy exhibiting these lesions, as well as a widening of the outermost myelin lamellae in some fibers. Such associated lesions are classic in experimental inflammatory demyelinating polyradiculoneuropathies, but have not been reported in human pathology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687968
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Variability of morphological features in early infantile polyneuropathy with defective myelination (1987)
    Springer
    Acta neuropathologica 73 (1987), S. 295-300 
    Details
    ISSN: 1432-0533
    Keywords: Axon ; Myelin ; Infantile polyneuropathy ; Peripheral nerve ; Schwann cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four cases of early infantile polyneuropathy with defective myelination are reported. The peripheral nerve was studied by light and electron microscopy; different morphological characteristics have been noticed in these patients. Case 1 presented aspects of defective myelination with atypical “onion bulb” formation composed of multiple layers of basement membrane. In case 2, defective myelination and atypical “onion bulb” formation were associated with aberrant hypermyelination. Cases 3 and 4 were brothers, who presented axonal damage and atypical “onion bulb” formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686625
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Acute inflammatory demyelinating polyneuropathy in a diabetic patient: Predominance of vesicular disruption in myelin sheaths (1985)
    Springer
    Acta neuropathologica 67 (1985), S. 337-340 
    Details
    ISSN: 1432-0533
    Keywords: Diabetes mellitus ; Myelin ; Peripheral nerve ; Polyradiculoneuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A diabetic woman underwent an incision of the right big toe for an abscess and developed a typical Guillain-Barré syndrome 48 h later. A biopsy of a peripheral nerve, performed 10 days later, showed modifications usually seen in diabetic patients, as well as the characteristic ultrastructural modifications of the Guillain-Barré syndrome (GBS). Moreover, 22% of myelinated fibers exhibited vesicular disruption of the myelin sheaths. This lesion is rarely encountered on the biopsies of peripheral nerve in GBS and concerns only a few myelinated fibers. Such a prominence of myelinic vesicular disruption and its occurrence in a diabetic patient are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687823
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Uncompacted myelin lamellae in two cases of peripheral neuropathy (1983)
    Springer
    Acta neuropathologica 60 (1983), S. 252-256 
    Details
    ISSN: 1432-0533
    Keywords: Malignant lymphoma ; Monoclonal gammopathy ; Myelin ; Peripheral neuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Peripheral nerve biopsies from two patients with chronic sensorimotor neuropathy were studied. The first case was a non-Hodgkin malignant lymphoma and did not show any dysglobulinemia. The second case had a benign monoclonal gammopathy IgG, Lambda type. Direct immunofluorescence showed no deposits in the first case and slight deposits of anti IgG sera on a few myelinated fibers in the second case. There were numerous fibers showing uncompacted myelin lamellae, 7% in the first case and 4% in the second case. Some of these fibers had axons containing more tubules than filaments. The very few cases reported on neuropathies showing that uncompacted myelin lamellae were frequently associated with dysglobulinemic neuropathy. However, this ultrastructural abnormality of the myelin sheath can be observed without any dysglobulinemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691873
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    Paper (German National Licenses)
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