ISSN:
1438-2199
Keywords:
Amino acids
;
Non-proteinogenic dipeptides
;
Dehydrodipeptides
;
Diastereoselectivity
;
N-Boc-Dehydroamino acids
;
Asymmetric hydrogenation
;
Chiral rhodium catalysts
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary N-Boc protected non-proteinogenic dipeptides with D,L-and L,L-configuration were prepared by catalytic asymmetric hydrogenation of the corresponding dehydrophenylalanyl-(L)-phenylalanine derivatives. The configuration of the new stereogenic centre depends first of all on the catalyst configuration and is less influenced by the substrate configuration. Diastereomeric excesses in the range of 80–96% de could be increased up to 99% by recrystallization. Analytical data of selected new compounds are given.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01361662
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