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  • 1
    ISSN: 1432-2013
    Keywords: Isolated Kidney ; Plasmamembranes ; Na−K-ATPase ; Na-Reabsorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The Na−K-ATPase-activity of the isolated, cell-free perfused rat kidney was investigated. Na-load and perfusion rate could be varied independently. The ATPase-assay was carried out on plasmamembranes (700–1200 g fraction) isolated and purified after 60 min perfusion. Both the specific Na−K-ATPase-activity and the fractional Na-reabsorption showed an indirect correlation with the Na-load as well as with the perfusion rate. The Na−K-ATPase-activity of plasmamembranes obtained from the isolated kidney at physiological Na-load fits well to control values prepared from unperfused control kidneys. The present data are in accord with the results of earlier micropuncture experiments, where acute saline loading diminished the rate of Na-reabsorption.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: PAH ; PAH-metabolism ; N-acetylation ; renal artery stenosis ; essential hypertension ; PAH ; PAH-Metabolismus ; N-Acetylierung ; Nierenarterien-Stenose ; essentielle Hypertonie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Routinemäßige PAH-Clearance-Untersuchungen wurden durchgeführt bei Patienten mit a) Glomerulonephritis, b) sekundärer Beeinträchtigung der Nierenfunktion, c) essentieller Hypertonie und d) bei Patienten mit einseitiger Nierenarterien-Stenose. Die renale Ausscheidung von N-Acetyl-PAH war signifikant erniedrigt bei Patienten mit Nierenarterien-Stenose oder mit essentieller Hypertonie, während die anderen Gruppen keine Störung des PAH-Metabolismus aufwiesen. Die Bedeutung dieser Befunde wird diskutiert.
    Notes: Summary Routine PAH-clearance studies were carried out on patients with (a) glomerulonephritis, (b) secondary impairment of renal function, (c) essential hypertension, and (d) patients with unilateral renal artery stenosis. Renal excretion of N-acetyl-PAH was significantly lower in patients with unilateral artery stenosis or with essential hypertension, while the other groups showed no impairment of the PAH-metabolism. The implications of these findings are discussed.
    Type of Medium: Electronic Resource
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