ISSN:
1573-4919
Keywords:
neutrophils
;
nifedipine
;
superoxide
;
chemotaxis
;
phagocytosis
;
NADPH
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Administration of nifedipine to mice over a period of six months caused a significant (p〈0.05) decrease in neutrophilic functions viz superoxide generation, coupled to NADPH oxidase activity as well as NADPH production by HMP shunt. Properties like chemotaxis and phagocytosis showed a similar decrease. From this study, it is seen that nifedipine causes neutrophil functional abrogation which is therefore an apparent concern for the prolonged usage of the drug. However, relevance of the mouse model to clinical situation needs further investigation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00925987
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