ISSN:
1432-1076
Keywords:
Nephrogenic diabetes insipidus
;
Heterogeneity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In congenital nephrogenic diabetes insipidus (NDI) blunted responses of plasma factor VIII, von Willebrand factor, and plasminogen activator to the synthetic V2 analogue 1-desamino-8-d-arginine vasopressin (DDAVP) have been reported. In addition, vasodilatory responses to DDAVP appear to be absent in NDI. We describe a boy, who presented shortly after birth with the typical features of NDI, but who showed normal coagulation, fibrinolytic and vasodilatory responses to DDAVP. We conclude that in this patient the defect is confined to the kidney, while in other NDI patients there may be a general V2 receptor abnormality. These findings point to heterogeneity in NDI.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01955943
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