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  • 1
    Electronic Resource
    Electronic Resource
    Single Na channels in mouse neuroblastoma cell membrane (1983)
    Springer
    Pflügers Archiv 399 (1983), S. 302-308 
    Details
    ISSN: 1432-2013
    Keywords: Neuroblastoma cell ; Patch clamp ; Single sodium channel ; Multiple open states
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Single sodium channel currents were studied in mouse neuroblastoma cells. Channel conductance (γ) was 11.6±3.4 pS at 6–8°C. Unitary current amplitudes and channel activity increased with increasing temperature. The Arrhenius plot of the conductance was linear between 5 and 35°C with an activation enthalpy of 27.1 kJ/mole (Q 10 =1.28). Amplitude distributions were fitted by the sum of two Gaussian functions indicating the presence of two different single channel amplitudes: smalleri 1 and largeri 2. The relative probability of appearance ofi 1, which has a shorter mean open time, was higher during the early phase of depolarization (t〈16 ms). The open time histograms, inactivating phase of macroscopic currents and delay time histograms were fitted by the sum of two exponentials. The distinct kinetic and steady-state parameters reflect two open states of sodium channels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00652757
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Metal ion-induced permeability changes in cell membranes: A minireview (1994)
    Springer
    Cellular and molecular neurobiology 14 (1994), S. 781-789 
    Details
    ISSN: 1573-6830
    Keywords: excitable membrane ; ionic channel ; heavy metal ; metal ion-induced current
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. The paper summarizes the effects of the metal ions Cu2+, Pb2+, Ag+, Hg2+, Zn2+, and Cd2+ applied externally or internally to the surface membrane of different excitable cells. 2. Conductance changes induced by metal ions, and metal ion-activated current, are compared with respect to their ion and voltage dependence. 3. It is suggested that metal ion-induced effects can be realized through special structures of the cell membrane, the metal ion “receptors,” although other mechanisms, as, for example, competition for Ca-binding sites in the channel forming proteins, cannot be excluded.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02088684
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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