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  • Paraneoplastic cerebellar degeneration  (3)
  • Neuropsychologische Veränderungen  (2)
  • 1
    ISSN: 1432-1459
    Keywords: Posturography ; Paraneoplastic cerebellar degeneration ; Cortical cerebellar atrophy ; Bronchogenic carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neurological examination and posturography showed cerebellar signs in 13 of 50 unselected patients with bronchogenic carcinoma not complicated by other diseases. The occurrence of cerebellar signs did not depend on the histological type of tumour or the extent of tumour spread. Most of the clinically affected patients had mild to pronounced cerebellar atrophy, revealed by CT. The correlation between the amount of CT-confirmed atrophy and the severity of clinical symptoms, however, was poor. Since other reasons for cerebellar dysfunction (e.g. chemotherapy, chronic alcoholism, metastases) were excluded, cerebellar signs were attributed to paraneoplastic cerebellar degeneration or to a consequence of severe neoplastic illness. The high incidence of cerebellar dysfunction in patients with bronchogenic carcinoma confirms the frequent histopathological finding of cortical cerebellar degeneration in malignant disease.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 235 (1987), S. 122-124 
    ISSN: 1432-1459
    Keywords: Paraneoplastic cerebellar degeneration ; Hodgkin's disease ; MRI ; Anti-Purkinje-cell antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of paraneoplastic cerebellar degeneration (PCD) associated with Hodgkin's disease is presented. The features that make this case particularly interesting are the simultaneous occurrence of PCD with a relapse of Hodgkin's disease, which has been present for 17 years, and the arrested progression of cerebellar dysfunction after a subacute onset. Cerebellar atrophy was revealed by computed tomography and magnetic resonance imaging. In contrast to two previously reported cases, anti-Purkinje-cell antibodies were not detected.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1459
    Keywords: Paraneoplastic cerebellar degeneration ; Anti-Purkinje cell antibodies ; Bronchogenic carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sera from seven patients with bronchogenic carcinoma and cerebellar dysfunction were tested for anti-Purkinje cell antibodies (APCA) by indirect immunofluorescence and indirect immunoperoxidase reaction. Specific APCA as described in paraneoplastic cerebellar degeneration (PCD) were not detected in any of these patients or in control patients. The lack of APCA in patients with bronchogenic carcinoma and their presence in association with ovarian or breast cancer indicate that different pathogenetic mechanisms may play a role in PCD.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1984), S. 74-77 
    ISSN: 1433-8491
    Keywords: Carotid endarterectomy ; Neuropsychological changes ; Endarterektomie ; Carotisstenose ; Neuropsychologische Veränderungen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir führten bei 23 Patienten mit uni- oder bilateralen hämodynamisch relevanten Carotisstenosen vor und zehn Monate nach einer Endarterektomie testpsychologische Untersuchungen durch. Präoperativ hatten die meisten Patienten TIA (15), fünf hatten einen leichten Schlaganfall erlitten, drei waren asymptomatisch. Die Nachuntersuchung zeigte leicht verbesserte intellektuelle Funktionen, während die mnestischen Funktionen eher schlechter waren als vor der Operation. Die psychomotorischen Funktionen zeigten — ebenso wie die persönlichkeitsbezogenen Tests — keine wesentlichen Unterschiede. Die prophylaktische Wirkung der Endarterektomie zur Vorbeugung von Schlaganfällen ist unumstritten; eine wesentliche Verbesserung der neuropsychologischen Veränderung ist aber in der Regel nicht zu erwarten
    Notes: Summary Psychological testing was performed on 23 patients (mean age 60.7 years) with unilateral or bilateral stenoses of the carotid arteries prior to and 10 months after carotid endarterectomy. Intellectual functions were slightly improved, mnemic functions impaired, psychomotor functions and dimension of personality remained unchanged. Carotid endarterectomy, although improving neuropsychological functions in a few cases, on average does not cause a significant improvement. This underscores the preventive character of the surgical intervention.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1984), S. 69-73 
    ISSN: 1433-8491
    Keywords: Extracranial vascular disease ; Neuropsychological deficit ; Carotisstenose ; Neuropsychologische Veränderungen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In der vorliegenden Studie wurden 33 Patienten mit hämodynamisch relevanten Carotisstenosen oder -verschlüssen psychodiagnostisch untersucht. 22 litten an transitorisch ischdmischen Attacken, 6 hatten einen leichten Schlaganfall erlitten, 5 waren asymptomatisch. Patienten mit hämodynamisch relevanten Carotisstenosen Im Vergleich mit der altersentsprechenden Normalpopulation waren die intellektuellen Funktionen intakt; es bestanden aber deutliche Einschränkungen im mnestischen Bereich, in der Aufmerksamkeit und im Bereich psychomotorischer Reaktionen. Für die Ausprägung der neuropsychologischen Ausfälle war es irrelevant, ob uni- oder bilatere Stenosen im Carotiskreislauf vorlagen. Die Untersuchung zeigt, daß auch bei asymptomatischen Patienten und solchen mit reversiblen neurologischen Ausfdllen bereits manifeste neuropsychische Störungen bestehen können.
    Notes: Summary A total of 33 patients with a relevant stenosis or occlusion of extracranial arteries were tested for a number of neuropsychological functions. Most of them [22] suffered from transient ischemic attacks, 6 from strokes, 5 were asymptomatic. Compared to an age-matched population of normals, patients showed an impairment in their mnemic functions, and attention under stress as well as in their psychomotor function. The degree of neuropsychological impairment was independent of the unilaterality or bilaterality of carotid stenoses. The results illustrate the neuropsychological deficit even in asymptomatic patients and those with complete recovery from transient neurological deficits.
    Type of Medium: Electronic Resource
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