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  • Non-linear optics  (1)
  • atomic force microscopy  (1)
  • bilateral  (1)
  • 1
    ISSN: 0022-328X
    Keywords: Diarylazo ; Ferrocene ; Non-linear optics ; Second harmonic generation ; Stilbenyl
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Breast cancer research and treatment 64 (2000), S. 241-251 
    ISSN: 1573-7217
    Keywords: breast cancer ; bilateral ; loss of heterozygosity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Women who develop bilateral breast cancer at an early age are likely to harbour germline mutations in breast cancer susceptibility genes. The aim of this study was to test for concordant genetic changes in left and right breast cancer of young women (age 〈50) with bilateral breast cancer that may suggest an inherited breast cancer predisposition. Microsatellite markers were used to test for loss of heterozygosity (LOH) in left and right tumours for 31 women with premenopausal bilateral breast cancer. Markers adjacent to or within candidate genes on 17p (p53), 17q (BRCA1), 13q (BRCA2), 11q (Ataxia Telangiectasia-ATM) and 3p (FHIT) were chosen. Mutational testing for BRCA1 and BRCA2 was performed for cases where blood was available. Concordant LOH in both left and right tumours was demonstrated for at least one of the markers tested in 16/31(54%) cases. Where allelic loss was demonstrated for both left and right breast cancer, the same allele was lost on each occasion. This may suggest a common mutational event. Four cases showed concordant loss of alleles in both left and right breast cancer at D17S791 (BRCA1). BRCA1 mutations were identified in two of these cases where blood was available. Four cases showed concordant LOH at D13S155 (BRCA2). Concordant LOH was further demonstrated in seven cases for D11S1778 (ATM) and four cases for D3S1300 (which maps to the FHIT gene), suggesting a possible role for these tumour suppressor genes in this subgroup of breast cancer patients. No concordant allelic loss was demonstrated for D17S786 suggesting that germline mutations in p53 are unlikely in such cases of bilateral breast cancer.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-2711
    Keywords: Millipede ; atomic force microscopy ; micromechanics ; data storage ; light scattering ; polymer flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The “Millipede” data storage concept is based on the parallel operation of a large number of micromechanical levers that function as AFM sensors. The technique holds promise to evolve into a novel ultrahigh-density, terabit-capacity, and high-data-rate storage technology. Thermomechanical writing and reading in very thin polymer (PMMA) films is used to store and sense 30–40 nm sized bits of similar pitch size, resulting in 400–500 Gbit/in2 storage densities. High data rates are achieved by operating very large arrays (32×32) of AFM sensors in parallel. Batch-fabrication of 32×32 AFM cantilever array chips has been achieved, and array reading and writing have been demonstrated. An important consideration for the Millipede storage project is the polymer dynamics on the size scale of one bit. Scaling of rheological parameters measured for macroscopic polymer samples is likely to be incorrect due to the finite length of the underlying molecular polymer chain, a size that is comparable to the bit itself. In order to shed light on these issues we performed lifetime studies of regular arrays of nanometer size patterns using light-scattering techniques.
    Type of Medium: Electronic Resource
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