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  • 1
    Electronic Resource
    Electronic Resource
    Chronic and acute administration of typical and atypical antidepressants on activity of brain noradrenaline systems in the rat thiopentone anaesthesia model (1984)
    Springer
    Psychopharmacology 84 (1984), S. 304-309 
    Details
    ISSN: 1432-2072
    Keywords: Noradrenaline ; Serotonin ; Dopamine ; Beta receptors ; Antidepressants ; Thiopentone ; Anaesthesia ; Rat ; Iprindole ; Mianserin ; Zimelidine ; Sleeping time
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A behavioural model sensitive to manipulation of brain noradrenaline systems and with characteristics of beta-receptor mediation has been developed using the duration of thiopentone anaesthesia in the rat. Acute and chronic administration of various antidepressant agents was examined. In the acute phase, (30 min prior to thiopentone) the noradrenaline uptake-inhibiting tricyclic drugs and viloxazine increased anaesthesia duration in a dose-dependent fashion. The atypical antidepressants trazodone, iprindole, and mianserin did this only weakly, while the dopaminergic and serotonergic uptake-inhibiting antidepressants (respectively bupropion, nomifensine, and zimelidine, fluoxetine) markedly shortened anaesthesia duration. Chronic administration (for 15 days) prolonged anaesthesia duration measured 2 or 5 days after the last drug injection for all tricyclic agents, for the atypical antidepressants mianserin, iprindole, fluoxetine, and zimelidine, and for viloxazine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00555203
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Behavioural evidence that chronic treatment with the antidepressant desipramine causes reduced functioning of brain noradrenaline systems (1983)
    Springer
    Psychopharmacology 81 (1983), S. 73-77 
    Details
    ISSN: 1432-2072
    Keywords: Noradrenaline ; 6-Hydroxydopamine ; Desipramine ; Antidepressants ; Thiopentone ; Anaesthesia ; Locus coeruleus ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A behavioral system sensitive to the net functional activity of the locus coeruleus noradrenergic system, with characteristics of a beta-adrenoceptor mediated response, has been developed based on the duration of thiopentone anaesthesia in the rat. The effects of acute and chronic treatment with the tricyclic antidepressant desipramine (DMI) were determined. Acute DMI from 5 to 25 mg/kg increased thiopentone sleeping-time in a dose-dependent fashion. This was due to an action on noradrenergic systems, since it was mimicked by treatment with the selective neurotoxin 6-hydroxydopamine, which itself increased thiopentone sleeping-time and prevented any additional effect of DMI. Chronic treatment with DMI had no effect on thiopentone sleeping-time when carried out for 2 or 5 days but markedly prolonged it when carried out for 10 or 20 days, thus paralleling the time course of clinical action of the drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00439277
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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