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  • 1
    Electronic Resource
    Electronic Resource
    Debrisoquine oxidative phenotyping and psychiatric drug treatment (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 53-58 
    Details
    ISSN: 1432-1041
    Keywords: debrisoquine metabolism ; psychiatric illness ; hydroxylation phenotype ; genetic polymorphism ; Psychotropic drugs ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The debrisoquine/sparteine phenotype was determined in 51 patients with depression, who were subdivided into 3 groups in terms of their drug treatment. Log (MR) for each group was compared. Patients treated with benzodiazepines had the same distribution of log (MR) as the healthy population, but the distribution was shifted towards higher values in patients treated with neuroleptics and antidepressants. It appears that the phenotypic expression of debrisoquine oxidation may be modified by drugs whose metabolism follows the same route as debrisoquine. The debrisoquine test must be carefully interpreted in patients receiving several drugs in the same time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561023
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Interaction between amitriptyline and phenothiazine in man: Effect on plasma concentration of amitriptyline and its metabolite nortriptyline and the correlation with clinical response (1979)
    Springer
    Psychopharmacology 65 (1979), S. 187-190 
    Details
    ISSN: 1432-2072
    Keywords: Amitriptyline ; Nortriptyline ; Drug interaction ; Therapeutic plasma concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Amitriptyline (AT) and nortriptyline (NT) plasma levels were checked in 86 patients treated with AT by oral or IM administration. Fifty-six patients were also treated with a phenothiazine. In 20 of these patients receiving AT IM with a phenothiazine, the plasma levels of NT (and the variability of these levels between patients) were higher than in nine patients receiving the antidepressant drug alone at the same dosage and by the same route. In eleven patients receiving AT orally with a phenothiazine the plasma levels of NT (and the variability of these levels between patients) were higher, and the ratio of plasma levels of AT and NT were lower than in eight patients receiving the antidepressant drug alone at the same dosage and by the same route. These results suggest an increase of the demethylation of AT and/or a decrease of the hydroxylation of NT and/or a decrease of its elimination. The differences in the variability of the plasma levels of AT and NT could be due to a saturation of the enzymatic system of biotransformation of the antidepressant drug by phenothiazine and to a first-pass effect when the drug is given orally. The correlation between the plasma levels of AT and NT and the clinical effect has been studied in the 86 patients. The correlation between the NT plasma level and the clinical response seems to be more curvilinear when AT is associated with a phenothiazine. This suggests a potentialization of the post-synaptic alpha-receptor blocking effect of NT by the neuroleptic drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433047
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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