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  • 1
    Electronic Resource
    Electronic Resource
    Tricyclic antidepressant plasma level monitoring: intraindividual variability in everyday practice (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 611-612 
    Details
    ISSN: 1432-1041
    Keywords: Tricyclic antidepressants ; plasma level monitoring ; intraindividual variability ; depressed patients ; amitriptyline ; clomipramine ; imipramine ; desimipramine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The intraindividual variability of tricyclic antidepressant plasma levels (amitriptyline, clomipramine, imipramine and desimipramine) has been examined twice in 127 depressed outpatients. The dosage, route of administration, concomitant drug therapy and clinical condition were identical on the two occasions, which were 1 to 2 months apart. The mean plasma levels of the antidepressant drug and its main metabolite did not differ significantly in the first and second blood samples, indicating little intraindividual variation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316109
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Amitriptyline: linear or nonlinear kinetics in every day practice? (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 595-598 
    Details
    ISSN: 1432-1041
    Keywords: amitriptyline ; nortriptyline ; pharmacokinetics ; linear kinetics ; depressed patients ; toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The linearity of the (AMT) kinetics of amitriptyline has been tested in 135 depressed dosed twice daily by measuring plasma. Their (AMT) and nortriptyline (NT) levels under steady-state conditions. The AMT concentration/dose ratios at low and high dosages were not significantly different and there was a linear relationship between the dose ratios and the concentration ratios. No change in the metabolic ratio (AMT/NT) was observed between the two dosages. Although the results are consistent with linear AMT kinetics, there may have been nonlinear kinetics in some patients as the ratio between the concentration/dose ratios in them at low and high dosages was greater than one. Those patients were characterized by a low concentration/dose ratio at low dosage. No clinical adverse effect appeared in the study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562551
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Interaction between amitriptyline and phenothiazine in man: Effect on plasma concentration of amitriptyline and its metabolite nortriptyline and the correlation with clinical response (1979)
    Springer
    Psychopharmacology 65 (1979), S. 187-190 
    Details
    ISSN: 1432-2072
    Keywords: Amitriptyline ; Nortriptyline ; Drug interaction ; Therapeutic plasma concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Amitriptyline (AT) and nortriptyline (NT) plasma levels were checked in 86 patients treated with AT by oral or IM administration. Fifty-six patients were also treated with a phenothiazine. In 20 of these patients receiving AT IM with a phenothiazine, the plasma levels of NT (and the variability of these levels between patients) were higher than in nine patients receiving the antidepressant drug alone at the same dosage and by the same route. In eleven patients receiving AT orally with a phenothiazine the plasma levels of NT (and the variability of these levels between patients) were higher, and the ratio of plasma levels of AT and NT were lower than in eight patients receiving the antidepressant drug alone at the same dosage and by the same route. These results suggest an increase of the demethylation of AT and/or a decrease of the hydroxylation of NT and/or a decrease of its elimination. The differences in the variability of the plasma levels of AT and NT could be due to a saturation of the enzymatic system of biotransformation of the antidepressant drug by phenothiazine and to a first-pass effect when the drug is given orally. The correlation between the plasma levels of AT and NT and the clinical effect has been studied in the 86 patients. The correlation between the NT plasma level and the clinical response seems to be more curvilinear when AT is associated with a phenothiazine. This suggests a potentialization of the post-synaptic alpha-receptor blocking effect of NT by the neuroleptic drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433047
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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