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  • 1
    Electronic Resource
    Electronic Resource
    Interaction between amitriptyline and phenothiazine in man: Effect on plasma concentration of amitriptyline and its metabolite nortriptyline and the correlation with clinical response (1979)
    Springer
    Psychopharmacology 65 (1979), S. 187-190 
    Details
    ISSN: 1432-2072
    Keywords: Amitriptyline ; Nortriptyline ; Drug interaction ; Therapeutic plasma concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Amitriptyline (AT) and nortriptyline (NT) plasma levels were checked in 86 patients treated with AT by oral or IM administration. Fifty-six patients were also treated with a phenothiazine. In 20 of these patients receiving AT IM with a phenothiazine, the plasma levels of NT (and the variability of these levels between patients) were higher than in nine patients receiving the antidepressant drug alone at the same dosage and by the same route. In eleven patients receiving AT orally with a phenothiazine the plasma levels of NT (and the variability of these levels between patients) were higher, and the ratio of plasma levels of AT and NT were lower than in eight patients receiving the antidepressant drug alone at the same dosage and by the same route. These results suggest an increase of the demethylation of AT and/or a decrease of the hydroxylation of NT and/or a decrease of its elimination. The differences in the variability of the plasma levels of AT and NT could be due to a saturation of the enzymatic system of biotransformation of the antidepressant drug by phenothiazine and to a first-pass effect when the drug is given orally. The correlation between the plasma levels of AT and NT and the clinical effect has been studied in the 86 patients. The correlation between the NT plasma level and the clinical response seems to be more curvilinear when AT is associated with a phenothiazine. This suggests a potentialization of the post-synaptic alpha-receptor blocking effect of NT by the neuroleptic drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433047
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Fluvoxamine-tricyclic antidepressant interaction (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 119-120 
    Details
    ISSN: 1432-1041
    Keywords: Fluvoxamine ; tricyclic antidepressants ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315151
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Biotransformation of amitriptyline in alcoholic depressive patients (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 615-621 
    Details
    ISSN: 1432-1041
    Keywords: amitriptyline ; biotransformation ; tricyclic antidepressants ; depression ; alcoholism ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The biotransformation of amitriptyline (AMT) during steady state conditions was studied in plasma and urine from 11 nonalcoholic and 10 alcoholic depressive inpatients treated with oral AMT. The 2 groups of patients had a different pattern of biotransformation. The Demethylation of AMT was lower in alcoholic than in nonalcoholic depressive patients, and conjugation and hydroxylation of AMT were also more marked in the former group. The results may be of clinical relevance since the conjugates of AMT are inactive.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542210
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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