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Digitale Medien

Rejection prophylaxis with sequential OKT3 and CSA after kidney transplantation (1990)

Weimar, W. ; Hesse, C. J. ; Vaessen, L. M. B. ; [weitere]

Springer

Biotherapy 2 (1990), S. 267-270

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Details

ISSN: 1573-8280

Schlagwort(e): kidney transplantation ; OKT3 ; rejection prophylaxis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Sixteen kidney transplant recipients received the IgG2a anti-CD3 monoclonal antibody OKT3 and azathioprine as rejection prophylaxis during the first two postoperative weeks. Concomitant immunosuppression consisted of low dose steroids while cyclosporine A therapy was instituted on day 12. Side effects included fever, bronchospasm, hypotension and diarrhoea. OKT3 caused T cell modulation resulting in CD3 dim +, CD4+ or CD8+, CD5+, WT31− and 11F2−cells. Anti-OKT3 antibodies were found in approximately 50% of the patients. The protocol induced a 100% patient and graft survival and a 81% actuarial freedom of rejection at 18 months. It prevented CsA associated nephrotoxicity in the direct postoperative phase. These beneficial effects outweighed the side effects of OKT3.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02173528

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