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  • 1
    Electronic Resource
    Electronic Resource
    The succinate dehydrogenase inhibition test for evaluating biopsy specimens and resected tumors of advanced gastric cancer (1992)
    Springer
    Surgery today 22 (1992), S. 508-511 
    Details
    ISSN: 1436-2813
    Keywords: SDI test ; chemosensitivity test ; MTT assay ; antitumor drug ; gastric cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An in vitro chemosensitivity study of both biopsy specimens and surgically resected tumors of advanced gastric cancer from 12 patients was evaluated using the succinate dehydrogenase inhibition (SDI) test. A decrease in succinate dehydrogenase (SD) activity as an indicator of chemosensitivity was determined using cisplatin (CDDP), etoposide (VP-16), and mitomycin C (MMC). In this study, 29 of a total 36 experiments were evaluable (80.6%) and significant correlations were found in all three of the antitumor drugs (P〈0.03). This finding suggests that the SDI test using biopsy specimens may prove valuable for assessing the preoperative chemosensitivity of advanced gastric cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308895
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  • 2
    Electronic Resource
    Electronic Resource
    Proliferation-associated nuclear antigen p105 as a marker for metastasis of human gastric cancer (1991)
    Springer
    Journal of cancer research and clinical oncology 117 (1991), S. 583-586 
    Details
    ISSN: 1432-1335
    Keywords: Proliferation-associated nuclear antigen ; p105 ; gastric cancer ; metastasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The expression of the proliferation-associated nuclear antigen p105 in 43 patients with advanced gastric carcinoma was studied by multiparameter flow cytometry. The p105 immunofluorescence intensity of tumor cells in the G0G1 phase was 1.8–14.5 times that in stromal cells, and the stromal cells could be separated by flow cytometry. The p105 intensity, which is the ratio of the mean fluorescence intensity of cancer cells to that of stromal cells in the G0G1 phase, was not correlated with the DNA index, the size of the S-phase fraction, or the histological type of the tumor. However, the intensity was significantly greater in patients with hepatic metastasis and significantly lower in patients with peritoneal metastasis. The patients with a p105 intensity of 4.0 or more had a significantly higher incidence of hepatic metastasis (8/22; 36%). The patients with a p105 intensity of less than 4.0 had a significantly higher incidence of peritoneal metastasis (8/21; 38%). These results suggest that the p105 intensity is a marker of metastasis useful in the treatment and follow-up of patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01613292
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  • 3
    Electronic Resource
    Electronic Resource
    Membrane-type 1 matrix metalloproteinase enhances lymph node metastasis of gastric cancer (2000)
    Springer
    Clinical & experimental metastasis 18 (2000), S. 321-327 
    Details
    ISSN: 1573-7276
    Keywords: gastric cancer ; lymph node metastases ; MT1-MMP ; NMP-2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The mechanisms of the lymph node metastasis remain unclear. We demonstrate the role of MT1-MMP on the lymph node metastasis using in vivo experimental model of lymph node metastasis by orthotopic implantation of MT1-MMP transfected gastric cancer cell line in the stomach of nude rats. TMK-1 cell line without expression of MT1-MMP was transfected with the pcDNA3 plasmid containing a 3.4-kb MT1-MMP cDNA fragment by calcium phosphate method, and the transfected cell line was designated as TMK-MT. Western blot and RT-PCR analyses showed the specific bands corresponding to MT1-MMP in the TMK-MT cells. By gelatin zymography, the activated form (62-kDa) of MMP-2 was identified in the medium of TMK-MT cell line, but was not detected in TMK-1 cells. Six weeks after orthotopic implantation of TMK-1 and TMK-MT xenografts of nude mouse-subcutaneus tumor into the stomach of nude rats, gastric tumors were found in all the animals. Histologically, the lymphatic invasion was found in the submucosa of the TMK-MT gastric tumors. Lymph node metastasis was not detected in nude rats bearing TMK-1 gastric tumor (0/8). In contrast, lymph node metastasis was detected in five out of 8 rats, bearing TMK-MT gastric tumor. MT1-MMP immunoreactivity was found on the cell membrane and cytoplasm of TMK-MT cells not only in the lymph node metastasis but also in the stomach tumor. These results suggest that MT1-MMP overexpression induced by transfection of its gene may promote lymph node metastasis of transformed cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1010887014669
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  • 4
    Electronic Resource
    Electronic Resource
    Biologically active glycosides from asteroidea, XXXII. Glycosphingolipids from the starfish Astropecten latespinosus, 2. Structure of two new ganglioside molecular species and biological activity of the ganglioside (1995)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1995 (1995), S. 545-550 
    Details
    ISSN: 0947-3440
    Keywords: Glycosphingolipids ; Gangliosides ; Starfish ; Astropecten latespinosus ; Antitumor activity ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Two ganglioside molecular species [LG-1 (1) and LG-2 (5)] have been obtained from the water-soluble lipid fraction of the chloroform/methanol extract of the starfish Astropecten latespinosus. On the basis of chemical and spectroscopic findings, the structure of 1 and 5 have been elucidated. They are new ganglioside molecular species. Negative FAB mass spectrometry provided important information both on the structure of the sugar moiety and on the molecular mass of the gangliosides. Partial hydrolysis by hot water has proved useful for structure elucidation of the complex oligosaccharide moieties. In addition, the major ganglioside molecular species, LG-2 (5), shows antitumor activity against murine lymphoma L1210 cells in vitro.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.199519950374
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  • 5
    Electronic Resource
    Electronic Resource
    Biologically active glycosides from asteroidea, XVI. Steroid oligoglycosides from the starfish Asterina pectinifera Müller et Troschel, 3 structures of two new oligoglycoside sulfates, pectiniosides E and F, and biological activities of the six new pectiniosides (1988)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1988 (1988), S. 845-850 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Biologisch aktive Glycoside aus Asteroidea, XVI.  -  Steroid-Oligoglycoside aus dem Seestern Asterina pectinifera Müller et Troschel, 3. - Die Strukturen von zwei neuen Oligoglycosidsulfaten, Pectiniosid E und F sowie die biologischen Aktivitäten der sechs neuen PectiniosideAus dem wäßrigen Extrakt der ganzen Seesterne Asterina pectinifera Müller et Troschel konnten nach chromatographischen Trennungen an Kieselgel RP-8 und Sephadex LH-20 zwei weitere neue Oligoglycosidsulfate, Pectiniosid E (1) und F (2), isoliert werden. Auf Grund chemischer und spektroskopischer Beweise wurden die Strukturen von 1 und 2 ermittelt. Außerdem wurde der Antitumoreffekt der Glycosidsulfate Pectiniosid A, B, C, D, E und F gegen die Mäuse-Lymphoma-L1210-Zelle und Human-Epidermoid-Carcinoma-KB-Zelle in vitro untersucht.
    Notes: Two further new oligoglycosides sulfates named pectinioside E (1) and F (2) were isolated from aqueous extracts of the whole bodies of Asterina pectinifera Müller et Troschel, after separation by column chromatography on silica gel, RP-8, and Sephadex LH-20. Their structures have been elucidated by chemical and spectroscopic means. In addition, we examined the antitumor effect of pectiniosides A, B, C, D, E, and F against murine lymphoma L1210 cells and human epidermoid carcinoma KB cells in vitro.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198819880905
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  • 6
    Electronic Resource
    Electronic Resource
    Biologically active glycosides from asteroidea, XVIII. 1H-NMR spectroscopy and biological activities of polyhydroxylated steroids from the starfish Asterina pectinifera Müller et Troschel (1988)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1988 (1988), S. 1185-1189 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Biologisch aktive Glycoside aus Asteroidea, XVIII. - 1H-NMR-Spektroskopie und biologische Aktivitäten der polyhydroxylierten Steroide aus dem Seestern Asterina pectinifera Müller et TroschelDie aus dem Seestern Asterina pectinifera Müller et Troschel erhaltenen Acetate von polyhydroxylierten Steroiden wurden 1H-NMR-spektroskopisch untersucht. Die 1H-NMR-Spektren von fünf Acetaten polyhydroxylierter Cholestane wurden in Deuteriochloroform- und Deuteriopyridin-Lösungen gemessen und verglichen. Es wurden deutliche Unterschiede zwischen den Spektren in beiden Lösungsmitteln beobachtet. Die Spektren in Deuteriopyridin lieferten mehr Informationen zur Struktur der ursprünglichen polyhydroxylierten Cholestane als die in Deuteriochloroform. Isolierung und Strukturaufklärung der zwei neuen polyhydroxylierten Cholestane 1 und 8 werden ebenfalls beschrieben. Außerdem wurden die Antitumor-Aktivitäten einiger polyhydroxylierter Steroide dieses Seesterns untersucht.
    Notes: The acetates of polyhydroxylated steroids obtained from the starfish Asterina pectinifera Müller et Troschel were studied by 1H-NMR spectroscopy. The 1H-NMR spectra of five kinds of acetates of polyhydroxylated cholestanes were measured in deuteriochloroform and deuteriopyridine solutions and then compared. Marked differences were observed between the spectra obtained in both solvents. The spectra in deuteriopyridine were more useful than those in deuteriochloroform in providing information on the structure of the parent polyhydroxylated cholestanes. The isolation and structures of the two new polyhydroxylated cholestanes 1 and 8 are also described. Moreover, the antitumor activities of some polyhydroxylated steroids from this starfish were examined.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198819881214
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  • 7
    Electronic Resource
    Electronic Resource
    Constituents of holothuroidea, II. Six newly identified biologically active triterpenoid glycoside sulfates from the sea cucumber Cucumaria echinata (1990)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1990 (1990), S. 453-460 
    Details
    ISSN: 0170-2041
    Keywords: Cucumaria echinata ; Sea cucumber ; Cucumariidae ; Triterpenoid glycoside sulfate ; Holostane derivative ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: From the whole body of sea cucumber Cucumaria echinata (Cucumariidae), we recently identified six genuine holostane-type triterpenoid glycoside sulfates designated as cucumechinoside A (1), B (2), C (3), D (4), E (5), and F (6). The structures 1-6 were determined on the basis of chemical and spectral investigations. Antitumor activities of these cucumechinosides and their solvolized compounds (10, 11, and 12) against murine lymphoma L 1210 and human epidermoid carcinoma KB cell in vitro were examined, and their antifungal and antiprotozoal activities were also investigated.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.199019900186
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